Gene Report

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Basic Info

Approved Symbol	MYH14
Previous Symbol	DFNA4
Symbol Alias	FLJ13881, KIAA2034, MHC16, MYH17
Approved Name	myosin, heavy chain 14, non-muscle
Previous Name	myosin, heavy polypeptide 14, "myosin, heavy chain 14"
Location	19q13.33
Position	chr19:50188186-50310545, 1
External Links	HGNC: 23212 Entrez Gene: 79784 Ensembl: ENSG00000105357 UCSC: uc010enu.1
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs1670725, rs3745504, rs8112504, rs8112720	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 26)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016020	membrane	cellular component	IDA[19946888]	137
GO:0007411	axon guidance	biological process	TAS	60
GO:0005516	calmodulin binding	molecular function	IEA	20
GO:0051015	actin filament binding	molecular function	IDA[24072716]	9

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005524	ATP binding	molecular function	IEA	118
GO:0042641	actomyosin	cellular component	IDA[24072716]	2
GO:0003009	skeletal muscle contraction	biological process	IMP[21480433]	4
GO:0030426	growth cone	cellular component	IEA	22
GO:0007519	skeletal muscle tissue development	biological process	IMP[21480433]	6
GO:0030424	axon	cellular component	IEA	39
GO:0070062	extracellular vesicular exosome	cellular component	IDA[19056867]	176
GO:0030898	actin-dependent ATPase activity	molecular function	IDA[24072716]	1
GO:0016460	myosin II complex	cellular component	IDA[24072716]	3
GO:0007605	sensory perception of sound	biological process	IMP[21480433]	18
GO:0000146	microfilament motor activity	molecular function	IEA	2
GO:0070584	mitochondrion morphogenesis	biological process	IMP[21480433]	1
GO:0008152	metabolic process	biological process	IDA[24072716]; IEA	50
GO:0030048	actin filament-based movement	biological process	IEA	2
GO:0001725	stress fiber	cellular component	IEA	3
GO:0019228	neuronal action potential	biological process	IMP[21480433]	11
GO:0008360	regulation of cell shape	biological process	IEA	16
GO:0005737	cytoplasm	cellular component	IEA	322
GO:0071625	vocalization behavior	biological process	IMP[21480433]	5
GO:0031032	actomyosin structure organization	biological process	IDA[24072716]	2
GO:0048013	ephrin receptor signaling pathway	biological process	TAS	11
GO:0097513	myosin II filament	cellular component	IDA[24072716]	1

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04530	Tight junction	18

ID	Name	No. of Genes in BDgene	Brief Description
hsa04810	Regulation of actin cytoskeleton	24

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 4)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs1670725	chr19:50269877 - 50269877(1)	intron_variant	1(0/1/0)
rs8112504	chr19:50267929 - 50267929(1)	intron_variant; upstream_gene_variant	1(0/1/0)
rs8112720	chr19:50268065 - 50268065(1)	intron_variant; upstream_gene_variant	1(0/1/0)
rs3745504	chr19:50268352 - 50268352(1)	5_prime_UTR_variant; intron_variant; synonymous_variant	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
19p13-q13	chr19:0-58617616	1 (0/1/0)
Chr 19	chr19:0-58617616	2 (0/2/0)
19q13	chr19:31900000-58617616	2 (0/2/0)
19q13.33-qter	chr19:47500000-58617616	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr19:50188186..50310545 View in gBrowse