Gene Report

Basic Info
Approved Symbol LRP8
Symbol Alias APOER2, MCI1, LRP-8, HSZ75190
Approved Name low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
Location 1p32.3
Position chr1:53242364-53328070, -1
External Links HGNC: 6700
Entrez Gene: 7804
Ensembl: ENSG00000157193
UCSC: uc001cvi.3
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? NO
Overlap with MDD? YES
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Li, M., 2015 SNP: rs5174 P-value=0.0048. LRP8 participates in the highly interconnected network formed by these susceptibility genes, implying that LRP8 is involved in the common molecular network that modulates the risk for psychosis. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 41)

GO terms by PBA (count: 5)

GO terms by database search (count: 36)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 2)

BioCarta pathways by PBA (count: 1)

BioCarta pathways by database search (count: 1)

Gene related interactors from protein-protein interactions data in HPRD (count: 8)

Related other genetic factors
Gene related SNPs (count: 25)

Literature-origin SNPs (count: 1)

LD-proxies (count: 24)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 1)

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Region: chr1:53242364..53328070 View in gBrowse
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