Gene Report

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Basic Info

Approved Symbol	TDRD9
Previous Symbol	C14orf75
Symbol Alias	DKFZp434N0820, FLJ36164, NET54
Approved Name	tudor domain containing 9
Previous Name	chromosome 14 open reading frame 75
Location	14q32.33
Position	chr14:103928462-104052667, 1
External Links	HGNC: 20122 Entrez Gene: 122402 Ensembl: ENSG00000156414 UCSC: uc001yom.4
No. of Studies	3 (Positive: 1; Negative: 1; trend: 1)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 3)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Moskvina, V.,2009		In BP:Smallest P-value per gene=<0.00001, Product of P truncation <=0.01=0.00521, Product of P truncation <=0.001=0.00092. It showed evidence for association with BD.	Positive	Comment on Study
Feng, T.,2010	SNP: rs11622475	This gene showed moderate association evidence.	Trend	Comment on Study
Ollila, H. M.,2009	SNP: rs11622475	It showed no evidence for association with BPI in our study.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IBA; ISS	283
GO:0007275	multicellular organismal development	biological process	IEA	24
GO:0030154	cell differentiation	biological process	IEA	31

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0071547	piP-body	cellular component	ISS	1
GO:0004004	ATP-dependent RNA helicase activity	molecular function	IBA	4
GO:0010467	gene expression	biological process	TAS	41
GO:0005524	ATP binding	molecular function	IEA	118
GO:0034587	piRNA metabolic process	biological process	ISS; TAS	2
GO:0007283	spermatogenesis	biological process	ISS	29
GO:0031047	gene silencing by RNA	biological process	IEA	3
GO:0044822	poly(A) RNA binding	molecular function	IBA	44
GO:0006396	RNA processing	biological process	IBA	4
GO:0043046	DNA methylation involved in gamete generation	biological process	ISS	2
GO:0007140	male meiosis	biological process	ISS	1
GO:0043186	P granule	cellular component	IBA	2
GO:0009566	fertilization	biological process	ISS	2

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 10)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs11622475	chr14:104042739 - 104042739(1)	intron_variant	4(0/1/3)
rs8021692	chr14:103962239 - 103962239(1)	intron_variant; non_coding_transcript_variant	1(0/0/1)

rs_ID	Location	Functional Annotation
rs10149651	chr14:103928103 - 103928103(1)	intron_variant; upstream_gene_variant
rs1187448	chr14:103940290 - 103940290(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant
rs6576012	chr14:103933822 - 103933822(1)	intron_variant; non_coding_transcript_variant
rs12886745	chr14:104057502 - 104057502(1)	downstream_gene_variant
rs11625697	chr14:103998463 - 103998463(1)	intron_variant
rs12885873	chr14:103969123 - 103969123(1)	downstream_gene_variant; intron_variant; upstream_gene_variant
rs941946	chr14:104037325 - 104037325(1)	intron_variant
rs12889168	chr14:104015620 - 104015620(1)	downstream_gene_variant; intron_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 2)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
TDRD9_Chr14:103464808		Exonic	1 (0/0/1)
TDRD9_Chr14:103576402		Exonic	1 (0/0/1)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
14q32	chr14:89300000-107043718	1 (0/1/0)
Chr 14	chr14:0-107043718	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
19065143	It showed no evidence for association with SZ.	Negative

Gene relationship with MDD

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Region: chr14:103928462..104052667 View in gBrowse