Gene Report

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Basic Info

Approved Symbol	PPP1R9A
Symbol Alias	Neurabin-I, KIAA1222, FLJ20068
Approved Name	protein phosphatase 1, regulatory subunit 9A
Previous Name	protein phosphatase 1, regulatory (inhibitor) subunit 9A
Location	7q21.3
Position	chr7:94907202-95296415, 1
External Links	HGNC: 14946 Entrez Gene: 55607 Ensembl: ENSG00000158528 UCSC: uc011kif.3
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Georgi, B., 2014	SNP: rs149869201	Putative damaging exonic variant was found within this gene.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0031175	neuron projection development	biological process	IEA	10
GO:0051015	actin filament binding	molecular function	IEA	9
GO:0045202	synapse	cellular component	IEA	29

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007015	actin filament organization	biological process	IEA	7
GO:0030426	growth cone	cellular component	IEA	22
GO:0005515	protein binding	molecular function	IPI[17464283]	563
GO:0030175	filopodium	cellular component	IEA	5
GO:0030054	cell junction	cellular component	IEA	88
GO:0030864	cortical actin cytoskeleton	cellular component	IEA	2
GO:0043197	dendritic spine	cellular component	IEA	21
GO:0019722	calcium-mediated signaling	biological process	IEA	9

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 7)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
PPP1R9A	TGOLN2	NO	in vitro;in vivo;yeast 2-hybrid	10514494
PPP1R9A	ACTG1	NO	in vitro;in vivo	9362513 , 12052877
PPP1R9A	RPS6KB1	NO	in vitro;in vivo;yeast 2-hybrid	12052877 , 9653190
PPP1R9A	PPP1R9B	NO	in vitro;in vivo;yeast 2-hybrid	10514494
PPP1R9A	PRKAR1B	NO	in vitro;in vivo	12052877
PPP1R9A	PPP1CA	NO	in vitro;in vivo;yeast 2-hybrid	12052877 , 10504266
PPP1R9A	PPP1R2	YES	in vitro;in vivo	12270929

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs149869201	chr7:95288582 - 95288582(1)	intron_variant; missense_variant	1(0/0/1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
7q21	chr7:77900000-98400000	4 (0/2/2)
7q21.3	chr7:93300000-98400000	1 (0/1/0)
7q21-31	chr7:77900000-127500000	1 (1/0/0)
Chr 7	chr7:0-159345973	3 (0/3/0)
7p15-q21	chr7:20900000-98400000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr7:94907202..95296415 View in gBrowse