Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	HSPA5
Previous Symbol	GRP78
Symbol Alias	BiP
Approved Name	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
Previous Name	heat shock 70kD protein 5 (glucose-regulated protein, 78kD)
Location	9q33.3
Position	chr9:125234853-125241330, -1
External Links	HGNC: 5238 Entrez Gene: 3309 Ensembl: ENSG00000044574 UCSC: uc004bpn.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Yosifova, A.,2009	SNP: rs1140763, rs12009, rs17840761, rs391957	No SNP of this gene had significant association with BD in our population.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 53)

GO terms by PBA (count: 5)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	IEA	360
GO:0016020	membrane	cellular component	IDA[19946888]	137
GO:0005634	nucleus	cellular component	IDA[21630459]; IMP[11943137]	283
GO:0019904	protein domain specific binding	molecular function	IPI[12411443]	24
GO:0005509	calcium ion binding	molecular function	TAS[16130169]	50

GO terms by database search (count: 48)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005515	protein binding	molecular function	IPI[11907036]	563
GO:0090074	negative regulation of protein homodimerization activity	biological process	TAS[14685163]	1
GO:0009986	cell surface	cellular component	IEA	40
GO:0019899	enzyme binding	molecular function	IPI[23921388]	34
GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	biological process	TAS[14685163]	3
GO:0051087	chaperone binding	molecular function	TAS[19816510]	10
GO:0007596	blood coagulation	biological process	TAS	44
GO:0021589	cerebellum structural organization	biological process	IEA	2
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	cellular component	IDA[15308636]	3
GO:0044267	cellular protein metabolic process	biological process	TAS	28
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	biological process	IEA	3
GO:0071353	cellular response to interleukin-4	biological process	IEA	4
GO:1901998	toxin transport	biological process	IEA	4
GO:0060904	regulation of protein folding in endoplasmic reticulum	biological process	TAS[19816510]	1
GO:0030335	positive regulation of cell migration	biological process	IMP[23990668]	16
GO:0005783	endoplasmic reticulum	cellular component	IDA[16223484]; IMP[11943137]; TAS[16130169]	49
GO:0030176	integral component of endoplasmic reticulum membrane	cellular component	IDA[11181571]	4
GO:0043066	negative regulation of apoptotic process	biological process	IMP[10760948]; TAS[16130169]	46
GO:0042149	cellular response to glucose starvation	biological process	IDA[10085239]	7
GO:0008180	COP9 signalosome	cellular component	IDA[18850735]	4
GO:0031625	ubiquitin protein ligase binding	molecular function	IPI[8666824]	25
GO:0051787	misfolded protein binding	molecular function	IDA[18400946]	1
GO:0005524	ATP binding	molecular function	IEA	118
GO:0021680	cerebellar Purkinje cell layer development	biological process	IEA	3
GO:0001948	glycoprotein binding	molecular function	IPI[20477988]	4
GO:0034975	protein folding in endoplasmic reticulum	biological process	TAS[22013210]	3
GO:0035437	maintenance of protein localization in endoplasmic reticulum	biological process	IMP[23990668]	1
GO:0034663	endoplasmic reticulum chaperone complex	cellular component	IDA[18400946]	1
GO:0030168	platelet activation	biological process	TAS	22
GO:0005925	focal adhesion	cellular component	IDA[21423176]	32
GO:0031398	positive regulation of protein ubiquitination	biological process	IEA	5
GO:0005789	endoplasmic reticulum membrane	cellular component	TAS	52
GO:0021762	substantia nigra development	biological process	IEP[22926577]	7
GO:0005790	smooth endoplasmic reticulum	cellular component	IEA	3
GO:0030968	endoplasmic reticulum unfolded protein response	biological process	TAS[19816510]	10
GO:0016887	ATPase activity	molecular function	IDA[23975754]; ISS	13
GO:0002576	platelet degranulation	biological process	TAS	5
GO:0070062	extracellular vesicular exosome	cellular component	IDA[19056867]	176
GO:0071236	cellular response to antibiotic	biological process	IEA	3
GO:0006987	activation of signaling protein activity involved in unfolded protein response	biological process	TAS	8
GO:0005788	endoplasmic reticulum lumen	cellular component	TAS	8
GO:0005739	mitochondrion	cellular component	IEA	75
GO:0042470	melanosome	cellular component	IEA	15
GO:0030496	midbody	cellular component	IDA[15166316]	8
GO:0006983	ER overload response	biological process	IEA	3
GO:0043022	ribosome binding	molecular function	IEA	2
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process	biological process	TAS[19816510]	3
GO:0051082	unfolded protein binding	molecular function	TAS[14685163]	6

Gene related KEGG pathways (count: 3)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 3)

ID	Name	No. of Genes in BDgene
hsa01510	Neurodegenerative Diseases	10
hsa05060	Prion disease	7
hsa04612	Antigen processing and presentation	7

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 34)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
HSPA5	LDLR	NO	in vivo	10906332
HSPA5	F8	NO	in vivo	9305856
HSPA5	CASP7	NO	in vivo	11943137
HSPA5	DPYSL5	NO	yeast 2-hybrid	16169070
HSPA5	PRNP	NO	in vivo	15146195
HSPA5	VWF	NO	in vivo	10887119
HSPA5	DNAJC1	NO	in vitro	10777498
HSPA5	SUMO4	NO	in vivo	16236267
HSPA5	TMEM132A	NO	in vitro;in vivo	12514190
HSPA5	TMEM62	NO	yeast 2-hybrid	16169070
HSPA5	PCSK7	NO	in vitro;in vivo	10964928
HSPA5	NDRG1	NO	in vivo	17220478
HSPA5	HLA-C	NO	in vivo	7957306
HSPA5	HSPBP1	NO	in vitro	19659607
HSPA5	EIF2AK3	NO	in vivo	11907036
HSPA5	A2M	NO	in vivo	12194978
HSPA5	DDX24	NO	yeast 2-hybrid	16169070
HSPA5	TRA@	NO	in vivo	1649196
HSPA5	MTNR1B	NO	in vivo	17215244
HSPA5	YWHAB	NO	in vivo	15324660
HSPA5	ERN1	NO	in vitro	12637535
HSPA5	TG	NO	in vitro	11294872 , 10049727
HSPA5	KRT8	NO	in vivo	9409741
HSPA5	SIL1	NO	in vitro;yeast 2-hybrid	12356756
HSPA5	PSME3	NO	yeast 2-hybrid	16169070
HSPA5	LCT	NO	in vivo	11751874
HSPA5	DNAJC10	NO	in vitro	12411443
HSPA5	STMN1	NO	in vitro;yeast 2-hybrid	10197448 , 7724523
HSPA5	BCAR1	NO	yeast 2-hybrid	16169070
HSPA5	KRT18	NO	in vivo	9409741
HSPA5	DPH1	NO	yeast 2-hybrid	11013075
HSPA5	ERP29	NO	in vitro;in vivo	9492298
HSPA5	TCERG1	NO	in vitro	15456888
HSPA5	IGHM	NO	in vivo	3122216

Related other genetic factors

Gene related SNPs (count: 4)

Literature-origin SNPs (count: 4)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs391957	chr9:125241745 - 125241745(1)	non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)
rs1140763	chr9:125235313 - 125235313(1)	3_prime_UTR_variant; downstream_gene_variant	1(0/1/0)
rs17840761	chr9:125241700 - 125241700(1)	non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)
rs12009	chr9:125235024 - 125235024(1)	3_prime_UTR_variant; downstream_gene_variant	1(0/1/0)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 9	chr9:0-138394717	3 (0/3/0)
9q33	chr9:114900000-127500000	1 (0/0/1)
9q33.3-34.3	chr9:123100000-138394717	1 (0/1/0)
9q32-q33	chr9:112100000-127500000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Reference	ID in SZGene	Result Category
16168956	210	Negative

Gene relationship with MDD

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Region: chr9:125234853..125241330 View in gBrowse