Gene Report

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Basic Info

Approved Symbol	SSTR5
Approved Name	somatostatin receptor 5
Location	16p13.3
Position	chr16:1078781-1080142, 1
External Links	HGNC: 11334 Entrez Gene: 6755 Ensembl: ENSG00000162009 UCSC: uc021taf.1
No. of Studies	2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	YES

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Nyegaard, M.,2002	Other variant: SSTR5_ -2134delT, SSTR5_A-1665G, SSTR5_C155T, SSTR5_C325T, SSTR5_C633T, SSTR5_C-801G, SSTR5_T-2187G, SSTR5_T-461C, SSTR5_G573A, SSTR5_C1004T, SSTR5_C142A	Our results may indicate that the SSTR5 gene is involved in the etiology of BPAD or may exist in linkage disequilibrium with a susceptibility gene close to SSTR5.	Positive	Comment on Study
Yosifova, A.,2009	SNP: rs169068	No SNP of this gene had significant association with BD in our population.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007268	synaptic transmission	biological process	IBA	116
GO:0005887	integral component of plasma membrane	cellular component	TAS[7908405]	158
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0042923	neuropeptide binding	molecular function	IBA	2

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0004994	somatostatin receptor activity	molecular function	IEA	2
GO:0007218	neuropeptide signaling pathway	biological process	IBA	18
GO:0043005	neuron projection	cellular component	IBA	38
GO:0007186	G-protein coupled receptor signaling pathway	biological process	TAS[9892014]	64
GO:0071392	cellular response to estradiol stimulus	biological process	IBA	8
GO:0008285	negative regulation of cell proliferation	biological process	TAS[9892014]	41
GO:0071385	cellular response to glucocorticoid stimulus	biological process	IBA	4
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	biological process	TAS[7908405]	17
GO:0032467	positive regulation of cytokinesis	biological process	IMP[22888021]	8
GO:0042593	glucose homeostasis	biological process	IEA	19
GO:0038170	somatostatin signaling pathway	biological process	IEA; TAS[9892014]	2
GO:0050796	regulation of insulin secretion	biological process	IBA	24

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	92

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 5)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
SSTR5	PEX5	NO	in vitro;in vivo;yeast 2-hybrid	16012170
SSTR5	ADCY10	YES	in vivo	9694905
SSTR5	PDZK1	NO	in vitro;in vivo;yeast 2-hybrid	16012170
SSTR5	GOPC	NO	in vitro;in vivo;yeast 2-hybrid	16012170
SSTR5	CORT	NO	in vivo	9205124 , 9125122

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs169068	chr16:1079872 - 1079872(1)	missense_variant; upstream_gene_variant	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 11)

Variant Name	Variant Type	No. of Studies (Positive/Negative/Trend)
SSTR5_C155T	point mutation	1 (0/1/0)
SSTR5_C325T	point mutation	1 (0/1/0)
SSTR5_C633T	point mutation	1 (0/1/0)
SSTR5_C-801G	point mutation	1 (0/1/0)
SSTR5_G573A	point mutation	1 (1/0/0)
SSTR5_T-2187G	point mutation	1 (0/1/0)
SSTR5_T-461C	point mutation	1 (0/1/0)
SSTR5_C142A	point mutation	1 (1/0/0)
SSTR5_C1004T	point mutation	1 (1/0/0)
SSTR5_A-1665G	point mutation	1 (0/1/0)
SSTR5_ -2134delT	insertion/deletion	1 (0/1/0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 16	chr16:0-90338345	5 (1/3/1)
16p13.3	chr16:0-7800000	2 (1/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

Reference	Description	Category in MDD	Link in MK4MDD
17130427	In analyzing the expression of 15 candidate genes for HIV encephalitis (HIVE) by the presence or absence of major depressive disorder (MDD), we noted significant reductions in the expression of four cytoskeletal genes and somatostatin. Whereas disruption of cytoskeletal genes has been noted in HIVE, dysregulation of somatostatin has not, indicating that dysregulation of somatostatin is part of the molecular pathologic process of MDD in the setting of HIV.	Pos	SSTR5

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Region: chr16:1078781..1080142 View in gBrowse