Gene Report

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Basic Info

Approved Symbol	DRP2
Approved Name	dystrophin related protein 2
Location	Xq22
Position	chrX:101219769-101264497, 1
External Links	HGNC: 3032 Entrez Gene: 1821 Ensembl: ENSG00000102385 UCSC: uc004egz.2
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Nakata, K.,2003(b)	Other variant: G'>DRP2_5'-flanking_-975C>G, DRP2_exon13_1506T>C, DRP2_exon14_*2236T>C, DRP2_exon4_352G>A, DRP2_exon4_426C>T	The present study did not provide any evidence for a contribution of the DRP-2 gene to susceptibility to BPD.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 5)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007417	central nervous system development	biological process	TAS[8640231]	21
GO:0005886	plasma membrane	cellular component	IEA	360

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005737	cytoplasm	cellular component	IEA	322
GO:0008270	zinc ion binding	molecular function	IEA	77
GO:0005856	cytoskeleton	cellular component	IEA	30

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 4)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
DRP2	UTRN	NO	in vitro	10767429
DRP2	DAG1	NO	in vivo;yeast 2-hybrid	11430802
DRP2	PRX	NO	in vitro;yeast 2-hybrid	11430802
DRP2	DTNA	NO	in vitro	10767429

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 5)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
DRP2_5'-flanking_-975C>G	point mutation	5'flanking	1 (0/1/0)
DRP2_exon13_1506T>C	point mutation	exon13	1 (0/1/0)
DRP2_exon4_352G>A	point mutation	exon4	1 (0/1/0)
DRP2_exon14_*2236T>C	point mutation	exon14	1 (0/1/0)
DRP2_exon4_426C>T	point mutation	exon4	1 (0/1/0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Xq21-q22	chrX:76800000-109400000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chrX:101219769..101264497 View in gBrowse