Gene Report

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Basic Info

Approved Symbol	LRBA
Previous Symbol	CDC4L
Symbol Alias	BGL, LAB300, LBA
Approved Name	LPS-responsive vesicle trafficking, beach and anchor containing
Location	4q13
Position	chr4:150264531-151015727, -1
External Links	HGNC: 1742 Entrez Gene: 987 Ensembl: ENSG00000198589 UCSC: uc003ilu.4
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Green, E. K.,2012	SNP: rs9834970	BD ImmunoChip:P-value = 0.0519,OR = 0.91;ImmunoChip, PGC-BD combined data:P-balue = 0.00000304,OR = 0.901 Suggestive association was found.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	IEA	360
GO:0016020	membrane	cellular component	IDA[19946888]	137
GO:0005764	lysosome	cellular component	IEA	16
GO:0016021	integral component of membrane	cellular component	IEA	219

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003674	molecular_function	molecular function	ND	24
GO:0016197	endosomal transport	biological process	IBA	3
GO:0005794	Golgi apparatus	cellular component	IEA	60
GO:0019898	extrinsic component of membrane	cellular component	IBA	8
GO:0005543	phospholipid binding	molecular function	IBA	8
GO:0005783	endoplasmic reticulum	cellular component	IEA	49
GO:0012505	endomembrane system	cellular component	IBA	9
GO:0008150	biological_process	biological process	ND	24
GO:0016023	cytoplasmic membrane-bounded vesicle	cellular component	IEA	16

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs9834970	chr3:36814539 - 36814539(1)	downstream_gene_variant	6(3/1/2)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 4	chr4:0-190214555	3 (0/3/0)
4q31.22-34.1	chr4:145900000-175400000	1 (0/0/1)
4q31	chr4:138500000-154600000	5 (1/0/4)
4q31-35	chr4:138500000-190214555	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr4:150264531..151015727 View in gBrowse