Gene Report

Basic Info
Approved Symbol ATP2A2
Previous Symbol ATP2B, DAR
Symbol Alias SERCA2
Approved Name ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
Name Alias sarcoplasmic/endoplasmic reticulum calcium ATPase 2, "calcium pump 2"
Location 12q24.11
Position chr12:110280756-110351093, 1
External Links HGNC: 812
Entrez Gene: 488
Ensembl: ENSG00000174437
UCSC: uc001tqk.4
No. of Studies 2 (Positive: 0; Negative: 2; trend: 0)
Overlap with SZ? NO
Overlap with MDD? NO
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Jacobsen, N. J.,2001(b) Other variant: ATP2A2_exon1_87C/T, ATP2A2_exon15_2172G/A, ATP2A2_exon15_2295G/A, ATP2A2_exon18_2697G/T, ATP2A2_intron3_220-18G/A, ATP2A2_promoter_-2549G/A Analysis of allele and genotype distributions for all six variations, and of haplotype frequencies showed no evidence for the involvement of ATP2A2 in producing susceptibility to bipolar disorder. Negative Comment on Study
Xu, W., 2014 SNP: rs11065615 In addition, a SNP in ATP2A2, the Darier disease gene (MIM#124200) also showed suggestive association (p = 2.67×10-5). Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 40)

GO terms by PBA (count: 4)

GO terms by database search (count: 36)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 4)

Related other genetic factors
Gene related SNPs (count: 2)

Literature-origin SNPs (count: 1)

LD-proxies (count: 1)

Gene related CNVs (count: 0)

Gene related other variants (count: 6)

Gene related regions (count: 4)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

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Region: chr12:110280756..110351093 View in gBrowse
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