Gene Report

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Basic Info

Approved Symbol	SLC22A16
Symbol Alias	FLIPT2, CT2, OKB1, OAT6
Approved Name	solute carrier family 22 (organic cation/carnitine transporter), member 16
Previous Name	solute carrier family 22 (organic cation transporter), member 16
Location	6q21
Position	chr6:110424687-110476641, -1
External Links	HGNC: 20302 Entrez Gene: 85413 Ensembl: ENSG00000004809 UCSC: uc003puf.4
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Fan, J., 2010	SNP: rs17071713, rs17071722, rs2428190, rs3823447, rs6938431, rs7768422, rs9400393	For gene-based test, P-value = 0.0013 in STEP1; P-value = 0.034 in NIMH; P-value = 0.00048 in STEP1 and NIMH; P-value = 0.03 in STEP2. nominally significant in all three samples	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	IC[15963465]; TAS	360
GO:0016021	integral component of membrane	cellular component	IDA[12089149]	219
GO:0030154	cell differentiation	biological process	IEA	31
GO:0007275	multicellular organismal development	biological process	IEA	24

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005275	amine transmembrane transporter activity	molecular function	IDA[15963465]	2
GO:0030317	sperm motility	biological process	IMP[12089149]	4
GO:0046717	acid secretion	biological process	IDA[12089149]	2
GO:0015879	carnitine transport	biological process	IDA[12089149]	1
GO:0015837	amine transport	biological process	IDA[15963465]	2
GO:0015226	carnitine transmembrane transporter activity	molecular function	IDA[12089149]	1
GO:0055085	transmembrane transport	biological process	TAS	77
GO:0015695	organic cation transport	biological process	IDA[12089149]	1
GO:0007338	single fertilization	biological process	IMP[12089149]	1
GO:0007283	spermatogenesis	biological process	IEA	29
GO:0015101	organic cation transmembrane transporter activity	molecular function	IDA[15963465]	1
GO:1902603	carnitine transmembrane transport	biological process	IDA[12089149]	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 16)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs2428190	chr6:110471098 - 110471098(1)	intron_variant; non_coding_transcript_variant	1(1/0/0)
rs7768422	chr6:110475202 - 110475202(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant	1(1/0/0)
rs6938431	chr6:110424403 - 110424403(1)	downstream_gene_variant	1(1/0/0)
rs17071722	chr6:110472889 - 110472889(1)	intron_variant; non_coding_transcript_variant	1(1/0/0)
rs3823447	chr6:110424616 - 110424616(1)	downstream_gene_variant	1(1/0/0)
rs17071713	chr6:110471889 - 110471889(1)	intron_variant; non_coding_transcript_variant	1(1/0/0)
rs9400393	chr6:110482811 - 110482811(1)	downstream_gene_variant	1(1/0/0)

rs_ID	Location	Functional Annotation
rs2428191	chr6:110471061 - 110471061(1)	intron_variant; non_coding_transcript_variant
rs2207356	chr6:110420408 - 110420408(1)	downstream_gene_variant; upstream_gene_variant
rs2428189	chr6:110471579 - 110471579(1)	intron_variant; non_coding_transcript_variant
rs4543405	chr6:110473914 - 110473914(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs17071719	chr6:110472667 - 110472667(1)	intron_variant; non_coding_transcript_variant
rs916719	chr6:110474346 - 110474346(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs3806970	chr6:110478345 - 110478345(1)	non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant
rs916721	chr6:110472447 - 110472447(1)	intron_variant; non_coding_transcript_variant
rs9487422	chr6:110472560 - 110472560(1)	intron_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
6q16-q21	chr6:100000000-114200000	1 (0/0/1)
Chr 6	chr6:0-170805979	3 (0/3/0)
6q21	chr6:105000000-114200000	4 (1/2/1)
6q14-22	chr6:75200000-130000000	1 (0/0/1)
6q21-22	chr6:105000000-130000000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr6:110424687..110476641 View in gBrowse