Gene Report

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Basic Info

Approved Symbol	ZIC2
Symbol Alias	HPE5
Approved Name	Zic family member 2
Previous Name	Zic family member 2 (odd-paired Drosophila homolog), "Zic family member 2 (odd-paired homolog, Drosophila)"
Name Alias	Zinc finger protein of the cerebellum 2
Location	13q32
Position	chr13:99981772-99986773, 1
External Links	HGNC: 12873 Entrez Gene: 7546 Ensembl: ENSG00000043355 UCSC: uc001von.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Fallin, M. D.,2005		3 SNP typed, Median D'=1, Median r<sup>2</sup> =0.18, 1 LD blocks, 0.64 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA... This gene is not suggestive to BP.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IDA; ISS	283
GO:0007420	brain development	biological process	TAS[9771712]	25
GO:0003677	DNA binding	molecular function	ISS	83
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	ISS	66

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	biological process	ISS	11
GO:0031490	chromatin DNA binding	molecular function	ISS	7
GO:0046872	metal ion binding	molecular function	IEA	115
GO:0005737	cytoplasm	cellular component	ISS	322
GO:0001843	neural tube closure	biological process	IEA	8
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:0007601	visual perception	biological process	ISS	15
GO:0045893	positive regulation of transcription, DNA-templated	biological process	ISS	58
GO:0031290	retinal ganglion cell axon guidance	biological process	IEA	2
GO:0045892	negative regulation of transcription, DNA-templated	biological process	ISS	43
GO:0048066	developmental pigmentation	biological process	IEA	2

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04340	Hedgehog signaling pathway	8

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
ZIC2	GLI1	NO	in vitro	11238441
ZIC2	GLI3	YES	in vivo	11238441
ZIC2	GLI2	YES	in vitro	11238441

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
13q32	chr13:98700000-101100000	9 (2/3/4)
13q21-33	chr13:54700000-109600000	1 (0/0/1)
13q22-32	chr13:72800000-101100000	1 (0/0/1)
13q31-q34	chr13:78500000-114364328	1 (0/0/1)
Chr 13	chr13:0-114364328	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
16380905	This gene is not suggestive to SZ/SZA.	Negative

Reference	ID in SZGene	Result Category
16380905	300	Negative

Gene relationship with MDD

View in gBrowse

Region: chr13:99981772..99986773 View in gBrowse