Gene Report

Basic Info
Approved Symbol SIRT1
Symbol Alias SIR2L1
Approved Name sirtuin 1
Previous Name sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 1, "sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)"
Location 10q21
Position chr10:67884669-67918390, 1
External Links HGNC: 14929
Entrez Gene: 23411
Ensembl: ENSG00000096717
UCSC: uc001jnd.3
No. of Studies 1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Kishi, T.,2011(a) SNP: rs10997875, rs12778366, rs2273773, rs4746720
Haplotype: rs12778366 - rs2273773 - rs4746720 - rs10997875(C-T-T-T), rs12778366 - rs2273773 - rs4746720 - rs10997875(T-C-T-T), rs12778366 - rs2273773 - rs4746720 - rs10997875(T-T-C-T), rs12778366 - rs2273773 - rs4746720 - rs10997875(T-T-T-C), rs12778366 - rs2273773 - rs4746720 - rs10997875(T-T-T-T)
Four tagging SNPs in the SIRT1 gene were not associated with BP in our sample. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 141)

GO terms by PBA (count: 2)

GO terms by database search (count: 139)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 1)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 1)

Gene related interactors from protein-protein interactions data in HPRD (count: 13)

Related other genetic factors
Gene related SNPs (count: 25)

Literature-origin SNPs (count: 4)

LD-proxies (count: 21)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 1)

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Region: chr10:67884669..67918390 View in gBrowse
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