Gene Report

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Basic Info

Approved Symbol	HTR7
Symbol Alias	5-HT7
Approved Name	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
Previous Name	5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)
Location	10q21-q24
Position	chr10:90740823-90857698, -1
External Links	HGNC: 5302 Entrez Gene: 3363 Ensembl: ENSG00000148680 UCSC: uc001kha.3
No. of Studies	2 (Positive: 0; Negative: 2; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Vincent, J. B.,1999(a)	Other variant: HTR7_XhoI Polymorphism	No significant differences were found in bipolar groups.	Negative	Comment on Study
Fallin, M. D.,2005		8 SNP typed, Median D'=1, Median r<sup>2</sup> =0.04, 2 LD blocks, 0.84 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA.. This gene is not suggestive to BP.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005887	integral component of plasma membrane	cellular component	TAS[8226867]	158
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0007268	synaptic transmission	biological process	IEA	116

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0008015	blood circulation	biological process	TAS[8226867]	6
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	biological process	TAS[8226867]	17
GO:0007623	circadian rhythm	biological process	IEA	40
GO:0042310	vasoconstriction	biological process	IEA	5
GO:0006939	smooth muscle contraction	biological process	IEA	7
GO:0004993	serotonin receptor activity	molecular function	IEA	12
GO:0007210	serotonin receptor signaling pathway	biological process	IEA; TAS[8226867]	12

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04020	Calcium signaling pathway	53

ID	Name	No. of Genes in BDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	92

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
HTR7	GPRASP2	NO	in vitro	15086532

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
HTR7_XhoI Polymorphism	SNP		1 (0/1/0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
10q22.3-23.32	chr10:75900000-92300000	1 (0/1/0)
10q22.1-q24.1	chr10:68800000-97500000	1 (1/0/0)
10q23.3	chr10:87700000-95300000	1 (0/1/0)
10q22.3-24.1	chr10:75900000-97500000	1 (0/1/0)
Chr 10	chr10:0-133797422	3 (0/2/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
16380905	This gene is not suggestive to SZ/SZA.	Negative

Gene relationship with MDD

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Region: chr10:90740823..90857698 View in gBrowse