Gene Report

Approved Symbol	DRD4
Approved Name	dopamine receptor D4
Location	11p15.5
Position	chr11:637293-640706, 1
External Links	HGNC: 3025 Entrez Gene: 1815 Ensembl: ENSG00000069696 UCSC: uc001lqp.2
No. of Studies	13 (Positive: 1; Negative: 12; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Perez de Castro, I.,1994	Other variant: DRD4_48bp repeat	X<sup>2</sup> = 2.9, df = 4, P-value = 0.57.. No significant association between bipolar affective disorder and DRD4 was found.	Negative	Comment on Study
Fallin, M. D.,2005		1 SNP typed, Median D'=…, Median r<sup>2</sup> =…, … LD blocks, … block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA.. This gene is not suggestive to BP.	Negative	Comment on Study
Leszczynska-Rodziewicz, A.,2005	Other variant: DRD4_-521T/C	The results suggests that the studied gene variants of type D2 dopamine receptors are not promising candidate genes for bipolar affective illness.	Negative	Comment on Study
Lopez Leon, S.,2005	Other variant: DRD4_exon3_VNTR	No evidence of significant association was found in BP group.	Negative	Comment on Study
De bruyn, A.,1994	Other variant: DRD4_HincII Polymorphism	Two-point linkage results excluded close linkage of bipolar illness to each candidate gene, and negative linkage results were obtained with the candidate genes DRD4, TH, TYR, and DRD2 under different genetic and phenotypic conditions	Negative	Comment on Study
Li, T.,1999	Other variant: DRD4_exon3_VNTR	We also report a novel, rare one-repeat variant of the DRD4 exon 3 VNTR repeat in Chinese populations, which appears to be absent in Caucasians and is not associated with disease.	Negative	Comment on Study
Manki, H.,1996	Other variant: DRD4_exon3_VNTR	Our results suggest that there is a significant association between the dopamine D4 receptor gene and mood disorders, especially major depression, but no association between the other polymorphisms and mood disorders.	Negative	Comment on Study
Szczepankiewicz, A., 2007	Other variant: DRD4_-521T/C	We have not found any significant differences in genotype distribution of the polymorphisms of this dopamine gene between bipolar disorder patients with/without comorbid alcohol abuse and controls.	Negative	Comment on Study
Oruc, L., 1997 (a)	Other variant: DRD4_2-10 allele	Therefore, the hypothesis that the tyrosine hydroxylase and the dopamine D4 receptor genes may be involved in the etiology of bipolar disorder and unipolar recurrent major depression is not supported in our study.	Negative	Comment on Study
Serretti, A.,2002	Other variant: DRD4_exon3_VNTR	Our study did not support the involvement of 5-HTTLPR, TPH, MAO-A, or DRD4 polymorphisms in bipolar disorder.	Negative	Comment on Study
Muglia, P.,2002	Other variant: DRD4_exon3_VNTR	Although replication of our study is necessary, the fact that DRD4 exhibit POE and is located on 11p15.5, in close proximity to a cluster of imprinted genes, suggests that genomic imprinting may be operating in bipolar disorder.	Positive	Comment on Study
Serretti, A.,2001(b)	Other variant: DRD4_exon3_VNTR	DRD4 allele and genotype frequencies in bipolars were not significantly different from controls.	Negative	Comment on Study
Bocchetta, A.,1999	Other variant: DRD4_exon3_VNTR	Using TDT, no significant differences were found with regard to DRD4, DRD2, DAT, and SERT polymorphism.	Negative	Comment on Study

Region: chr11:637293..640706 View in gBrowse