Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	AURKB
Previous Symbol	STK12
Symbol Alias	Aik2, IPL1, AurB, AIM-1, ARK2, STK5, PPP1R48
Approved Name	aurora kinase B
Previous Name	serine/threonine kinase 12
Name Alias	aurora-B, "aurora-1", "protein phosphatase 1, regulatory subunit 48"
Location	17p13.1
Position	chr17:8204733-8210600, -1
External Links	HGNC: 11390 Entrez Gene: 9212 Ensembl: ENSG00000178999 UCSC: uc002gkn.4
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Drago, A., 2016		Freq(Significant SNPs/total SNPs%)=0.02. Encodes for a member of the Aurora kinase subfamily of serine/threonine kinases. It is the catalytic component of the chromosomal passenger complex (CPC) that is critical for the correct progression through and completion of mitosis.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 39)

GO terms by PBA (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0004674	protein serine/threonine kinase activity	molecular function	IDA[22724069]	27
GO:0005634	nucleus	cellular component	IDA[20959462]	283

GO terms by database search (count: 37)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0000278	mitotic cell cycle	biological process	TAS	33
GO:0034501	protein localization to kinetochore	biological process	IMP[19468067]	1
GO:0030496	midbody	cellular component	IDA[17726514]; TAS[19774610]	8
GO:0031616	spindle pole centrosome	cellular component	IBA	2
GO:0008608	attachment of spindle microtubules to kinetochore	biological process	TAS[19774610]	1
GO:0008283	cell proliferation	biological process	IEA	37
GO:0051233	spindle midzone	cellular component	IBA	1
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	IDA[20959462]	62
GO:0051983	regulation of chromosome segregation	biological process	TAS[19774610]	1
GO:0043146	spindle stabilization	biological process	IMP[21820309]	1
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	biological process	TAS	3
GO:0036089	cleavage furrow formation	biological process	IDA[16103226]	1
GO:0005829	cytosol	cellular component	TAS	223
GO:0051256	mitotic spindle midzone assembly	biological process	IMP[16103226]; TAS[19774610]	1
GO:0005515	protein binding	molecular function	IPI[12689593]	563
GO:0032466	negative regulation of cytokinesis	biological process	ISS	1
GO:0005819	spindle	cellular component	TAS[19774610]	9
GO:0031577	spindle checkpoint	biological process	IEA	1
GO:0004712	protein serine/threonine/tyrosine kinase activity	molecular function	TAS[19774610]	4
GO:0035174	histone serine kinase activity	molecular function	IBA; ISS	1
GO:0007568	aging	biological process	IEA	22
GO:0010369	chromocenter	cellular component	IEA	1
GO:0005524	ATP binding	molecular function	IEA	118
GO:0034644	cellular response to UV	biological process	IDA[20959462]	5
GO:0046872	metal ion binding	molecular function	IEA	115
GO:0016570	histone modification	biological process	TAS[19774610]	1
GO:0043988	histone H3-S28 phosphorylation	biological process	ISS	1
GO:0046777	protein autophosphorylation	biological process	TAS[19774610]	16
GO:0000780	condensed nuclear chromosome, centromeric region	cellular component	IDA[18195732]	1
GO:0000779	condensed chromosome, centromeric region	cellular component	IDA[19465021]	1
GO:0009838	abscission	biological process	ISS	1
GO:0006468	protein phosphorylation	biological process	IDA[21820309]	42
GO:0032467	positive regulation of cytokinesis	biological process	IMP[16103226]; TAS[19774610]	8
GO:0005876	spindle microtubule	cellular component	IBA	2
GO:0002903	negative regulation of B cell apoptotic process	biological process	IDA[20959462]	1
GO:0032091	negative regulation of protein binding	biological process	IDA[21820309]	2
GO:0032133	chromosome passenger complex	cellular component	IPI[15260989]; TAS[19774610]	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 17)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
AURKB	NSUN2	YES	in vitro	17215513
AURKB	BIRC5	NO	in vitro;in vivo;yeast 2-hybrid	12419797 , 11516652 , 16291752
AURKB	DES	NO	in vitro	12686604
AURKB	RASA1	NO	in vivo;yeast 2-hybrid	11976319
AURKB	PSMA3	NO	in vitro;yeast 2-hybrid	14674694
AURKB	CENPA	NO	in vitro	11756469
AURKB	NDC80	NO	in vitro;in vivo	14602875
AURKB	SEPT1	NO	in vitro;in vivo;yeast 2-hybrid	16179162
AURKB	INCENP	NO	in vitro	12925766
AURKB	TBL3	NO	yeast 2-hybrid	16169070
AURKB	ANKZF1	NO	yeast 2-hybrid	16169070
AURKB	TACC1	NO	in vitro;in vivo	15064709
AURKB	HIST1H3A	NO	in vitro	10949293
AURKB	TGFBR1	NO	in vivo	15761153
AURKB	RACGAP1	NO	in vitro;in vivo	12689593 , 14744859 , 18201571
AURKB	CDCA8	NO	in vivo	15260989 , 15249581
AURKB	NUF2	YES	in vitro;in vivo	14602875

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
17p13.1-17p12	chr17:6500000-16100000	1 (0/1/0)
17p13	chr17:0-10800000	3 (0/3/0)
Chr 17	chr17:0-83257441	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr17:8204733..8210600 View in gBrowse