Gene Report

Basic Info
Approved Symbol AURKB
Previous Symbol STK12
Symbol Alias Aik2, IPL1, AurB, AIM-1, ARK2, STK5, PPP1R48
Approved Name aurora kinase B
Previous Name serine/threonine kinase 12
Name Alias aurora-B, "aurora-1", "protein phosphatase 1, regulatory subunit 48"
Location 17p13.1
Position chr17:8204733-8210600, -1
External Links HGNC: 11390
Entrez Gene: 9212
Ensembl: ENSG00000178999
UCSC: uc002gkn.4
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? NO
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Drago, A., 2016 Freq(Significant SNPs/total SNPs%)=0.02. Encodes for a member of the Aurora kinase subfamily of serine/threonine kinases. It is the catalytic component of the chromosomal passenger complex (CPC) that is critical for the correct progression through and completion of mitosis. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 39)

GO terms by PBA (count: 2)

GO terms by database search (count: 37)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 17)

Related other genetic factors
Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

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Region: chr17:8204733..8210600 View in gBrowse
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