Gene Report

ADD to My Gene Set

Basic Info

Approved Symbol	PLA2R1
Symbol Alias	PLA2G1R, PLA2IR, PLA2-R, CLEC13C
Approved Name	phospholipase A2 receptor 1, 180kDa
Previous Name	phospholipase A2 receptor 1, 180kD
Location	2q23-q24
Position	chr2:159932006-160062610, -1
External Links	HGNC: 9042 Entrez Gene: 22925 Ensembl: ENSG00000153246 UCSC: uc002ube.2
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Johnson, C.,2009		Monte-Carlo Simulation P-value = 0.0040. One of Genes That Harbor Overlapping Clusters of 4 Nominally Positive SNPs Whose Allele Frequencies Distinguish Individuals With Bipolar Disorder From Controls With P<0.05 Nominal Significance From at Least Three of the Four Samples in This Analysis	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 20)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0004872	receptor activity	molecular function	IDA[7721806]	19
GO:0016021	integral component of membrane	cellular component	IEA	219
GO:0043235	receptor complex	cellular component	IDA[23382219]	20
GO:0005886	plasma membrane	cellular component	IDA[12225974]	360
GO:0005887	integral component of plasma membrane	cellular component	NAS[7721806]	158
GO:0030246	carbohydrate binding	molecular function	IEA	6

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:1900138	negative regulation of phospholipase A2 activity	biological process	ISS	2
GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	biological process	IMP[19197340]	3
GO:0043274	phospholipase binding	molecular function	IPI[7721806]	4
GO:0090399	replicative senescence	biological process	IMP[19197340]	2
GO:0005576	extracellular region	cellular component	ISS; NAS[7721806]	97
GO:0090403	oxidative stress-induced premature senescence	biological process	IMP[19197340]	2
GO:0006898	receptor-mediated endocytosis	biological process	IDA[7721806]	12
GO:1900139	negative regulation of arachidonic acid secretion	biological process	ISS	1
GO:0006897	endocytosis	biological process	IEA	15
GO:0001816	cytokine production	biological process	IMP[15611272]	4
GO:0009986	cell surface	cellular component	IDA[15611272]	40
GO:0072593	reactive oxygen species metabolic process	biological process	IDA[19197340]	5
GO:0090238	positive regulation of arachidonic acid secretion	biological process	ISS	2
GO:0070062	extracellular vesicular exosome	cellular component	IDA[23376485]	176

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
PLA2R1	PLA2G2A	NO	in vitro	7721806
PLA2R1	PLA2G10	NO	in vitro;in vivo	11019817 , 10922494

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs4665146		chr2:160059572 - 160059572(1)	intron_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
2q24	chr2:154000000-168900000	4 (0/3/1)
2q21-q33	chr2:129100000-208200000	1 (0/0/1)
Chr 2	chr2:0-242193529	3 (0/3/0)
2q24-33	chr2:154000000-208200000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr2:159932006..160062610 View in gBrowse