BDgene

Gene Report

Basic Info
Approved Symbol FEZ1
Approved Name fasciculation and elongation protein zeta 1 (zygin I)
Location 11q24.2
Position chr11:125445745-125496317, -1
External Links HGNC: 3659
Entrez Gene: 9638
Ensembl: ENSG00000149557
UCSC: uc001qbx.3
No. of Studies 2 (Positive: 0; Negative: 2; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Hodgkinson, C. A., 2007 SNP: rs10893380, rs10893385, rs12223186, rs1365410, rs2241514, rs2702009, rs2907228, rs559668, rs597570
Haplotype: rs2702009 - rs559668 - rs597570 - rs10893385 - rs1365410 - rs12223186 - rs2241514 - rs2907228 - rs10893380(1-1-1-2-2-2-2-1-2), rs2702009 - rs559668 - rs597570 - rs10893385 - rs1365410 - rs12223186 - rs2241514 - rs2907228 - rs10893380(1-2-2-1-2-2-2-1-2), rs2702009 - rs559668 - rs597570 - rs10893385 - rs1365410 - rs12223186 - rs2241514 - rs2907228 - rs10893380(1-2-2-1-2-1-1-1-2), rs2702009 - rs559668 - rs597570 - rs10893385 - rs1365410 - rs12223186 - rs2241514 - rs2907228 - rs10893380(2-2-2-2-2-2-2-1-2), rs2702009 - rs559668 - rs597570 - rs10893385 - rs1365410 - rs12223186 - rs2241514 - rs2907228 - rs10893380(2-2-2-2-2-2-2-2-1)
No association to bipolar disorder was found for any of the nine markers typed in these populations at the allelic or the genotypic level. Additionally no association was found in either population between specific haplotypes and any of the psychiatric disorders. Variation at the FEZ1 locus does not play a significant role in the etiology of bipolar disorder in North American Caucasian or African American populations. Negative Comment on Study
Yamada, K.,2004 SNP: rs2241514, rs2702009, rs3217293, rs559688, rs597570
Other variant: FEZ1_IVS3+2509C>T, FEZ1_IVS4+1077T>C, FEZ1_IVS9+66A>T
No SNPs displayed allelic, genotypic, or haplotypic associations with bipolar disorder. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 19)

GO terms by PBA (count: 4)

GO terms by database search (count: 15)


Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 43)

Related other genetic factors
Gene related SNPs (count: 30)

Literature-origin SNPs (count: 11)

LD-proxies (count: 19)


Gene related CNVs (count: 0)

Gene related other variants (count: 3)

Gene related regions (count: 1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 2)

Overlap with SZ from candidate gene intersection analysis (count: 5)


Gene relationship with MDD

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Region: chr11:125445745..125496317 View in gBrowse
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