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Gene Report
| Basic information | Related studies | Functional annotation | Related other genetic factors | Overlap with SZ and MDD | ADD to My Gene Set | Comment on Gene | View All Comments on Gene |
| Approved Symbol | FEZ1 |
|---|---|
| Approved Name | fasciculation and elongation protein zeta 1 (zygin I) |
| Location | 11q24.2 |
| Position | chr11:125445745-125496317, -1 |
| External Links |
HGNC: 3659 Entrez Gene: 9638 Ensembl: ENSG00000149557 UCSC: uc001qbx.3 |
| No. of Studies | 2 (Positive: 0; Negative: 2; trend: 0) |
| Overlap with SZ? | YES |
| Overlap with MDD? | NO |
Gene related studies (count: 2)
| Reference | Tested Markers | Statistical Values/Author Comments | Result Category | Comment on Study |
|---|---|---|---|---|
| Hodgkinson, C. A., 2007 | SNP: rs10893380, rs10893385, rs12223186, rs1365410, rs2241514, rs2702009, rs2907228, rs559668, rs597570 Haplotype: rs2702009 - rs559668 - rs597570 - rs10893385 - rs1365410 - rs12223186 - rs2241514 - rs2907228 - rs10893380(1-1-1-2-2-2-2-1-2), rs2702009 - rs559668 - rs597570 - rs10893385 - rs1365410 - rs12223186 - rs2241514 - rs2907228 - rs10893380(1-2-2-1-2-2-2-1-2), rs2702009 - rs559668 - rs597570 - rs10893385 - rs1365410 - rs12223186 - rs2241514 - rs2907228 - rs10893380(1-2-2-1-2-1-1-1-2), rs2702009 - rs559668 - rs597570 - rs10893385 - rs1365410 - rs12223186 - rs2241514 - rs2907228 - rs10893380(2-2-2-2-2-2-2-1-2), rs2702009 - rs559668 - rs597570 - rs10893385 - rs1365410 - rs12223186 - rs2241514 - rs2907228 - rs10893380(2-2-2-2-2-2-2-2-1) |
No association to bipolar disorder was found for any of the nine markers typed in these populations at the allelic or the genotypic level. Additionally no association was found in either population between specific haplotypes and any of the psychiatric disorders. Variation at the FEZ1 locus does not play a significant role in the etiology of bipolar disorder in North American Caucasian or African American populations. | Negative | Comment on Study |
| Yamada, K.,2004 | SNP: rs2241514, rs2702009, rs3217293, rs559688, rs597570 Other variant: FEZ1_IVS3+2509C>T, FEZ1_IVS4+1077T>C, FEZ1_IVS9+66A>T |
No SNPs displayed allelic, genotypic, or haplotypic associations with bipolar disorder. | Negative | Comment on Study |
Gene functional annotation
Gene related GO terms (count: 19)
GO terms by PBA (count: 4)
| ID | Name | Type | Evidence[PMID] | No. of Genes in BDgene |
|---|---|---|---|---|
| GO:0007155 | cell adhesion | biological process | TAS[9096408] | 42 |
| GO:0007411 | axon guidance | biological process | TAS[9096408] | 60 |
| GO:0005886 | plasma membrane | cellular component | IEA | 360 |
| GO:0007399 | nervous system development | biological process | TAS[9096408] | 40 |
GO terms by database search (count: 15)
| ID | Name | Type | Evidence[PMID] | No. of Genes in BDgene |
|---|---|---|---|---|
| GO:0005739 | mitochondrion | cellular component | IEA | 75 |
| GO:0015630 | microtubule cytoskeleton | cellular component | IDA | 12 |
| GO:0010976 | positive regulation of neuron projection development | biological process | IEA | 10 |
| GO:0030424 | axon | cellular component | IEA | 39 |
| GO:0005080 | protein kinase C binding | molecular function | IEA | 7 |
| GO:0030425 | dendrite | cellular component | IEA | 65 |
| GO:0006810 | transport | biological process | IEA | 47 |
| GO:0047485 | protein N-terminus binding | molecular function | IEA | 12 |
| GO:0005813 | centrosome | cellular component | IEA | 34 |
| GO:0051654 | establishment of mitochondrion localization | biological process | IEA | 1 |
| GO:0005737 | cytoplasm | cellular component | IDA | 322 |
| GO:0005515 | protein binding | molecular function | IPI[14690447] | 563 |
| GO:0043015 | gamma-tubulin binding | molecular function | IEA | 2 |
| GO:0071363 | cellular response to growth factor stimulus | biological process | IEA | 8 |
| GO:0005874 | microtubule | cellular component | IEA | 24 |
Gene related KEGG pathways (count: 0)
Gene related BioCarta pathways (count: 0)
Gene related interactors from protein-protein interactions data in HPRD (count: 43)
| Gene | Interactor | Interactor in BDgene? | Experiment Type | PMID |
|---|---|---|---|---|
| FEZ1 | IMMT | NO | yeast 2-hybrid | 15383276 |
| FEZ1 | BARD1 | NO | yeast 2-hybrid | 15383276 |
| FEZ1 | CLASP2 | NO | in vitro;yeast 2-hybrid | 16484223 |
| FEZ1 | CIB1 | NO | in vitro;yeast 2-hybrid | 11856312 |
| FEZ1 | WWC1 | YES | in vitro;yeast 2-hybrid | 16484223 |
| FEZ1 | RAB3GAP2 | NO | yeast 2-hybrid | 16484223 |
| FEZ1 | CCL7 | NO | yeast 2-hybrid | 16169070 |
| FEZ1 | TXNDC9 | NO | yeast 2-hybrid | 16169070 |
| FEZ1 | FEZ2 | YES | yeast 2-hybrid | 16484223 |
| FEZ1 | BRD1 | YES | yeast 2-hybrid | 16484223 |
| FEZ1 | PTN | NO | yeast 2-hybrid | 15383276 |
| FEZ1 | SMEK2 | NO | yeast 2-hybrid | 16169070 |
| FEZ1 | C16orf59 | NO | yeast 2-hybrid | 16484223 |
| FEZ1 | SMARCD1 | NO | in vitro;yeast 2-hybrid | 16484223 |
| FEZ1 | STAR | NO | yeast 2-hybrid | 16169070 |
| FEZ1 | NBR1 | NO | in vivo;yeast 2-hybrid | 11856312 |
| FEZ1 | KIAA1377 | NO | yeast 2-hybrid | 15383276 |
| FEZ1 | DRAP1 | NO | in vitro;yeast 2-hybrid | 16484223 |
| FEZ1 | HTATSF1 | NO | yeast 2-hybrid | 16169070 |
| FEZ1 | SCOC | NO | yeast 2-hybrid | 16484223 |
| FEZ1 | TLK2 | NO | yeast 2-hybrid | 16484223 |
| FEZ1 | NDUFB9 | NO | yeast 2-hybrid | 16169070 |
| FEZ1 | PDCD7 | NO | yeast 2-hybrid | 16484223 |
| FEZ1 | OLFML3 | NO | yeast 2-hybrid | 16169070 |
| FEZ1 | TBC1D25 | NO | yeast 2-hybrid | 16484223 |
| FEZ1 | P4HB | NO | yeast 2-hybrid | 16169070 |
| FEZ1 | TTR | NO | yeast 2-hybrid | 16169070 |
| FEZ1 | C13orf34 | NO | yeast 2-hybrid | 16169070 |
| FEZ1 | DIS3L2 | NO | yeast 2-hybrid | 16169070 |
| FEZ1 | RAI14 | NO | in vitro;yeast 2-hybrid | 16484223 |
| FEZ1 | NEK1 | NO | in vitro;yeast 2-hybrid | 14690447 |
| FEZ1 | RIF1 | NO | yeast 2-hybrid | 15383276 |
| FEZ1 | CSTF2 | NO | yeast 2-hybrid | 16169070 |
| FEZ1 | PTPRS | NO | yeast 2-hybrid | 16169070 |
| FEZ1 | TAC3 | NO | yeast 2-hybrid | 16169070 |
| FEZ1 | GTF2F1 | NO | yeast 2-hybrid | 16169070 |
| FEZ1 | SMC3 | NO | in vitro;yeast 2-hybrid | 16484223 |
| FEZ1 | HEATR2 | NO | yeast 2-hybrid | 16169070 |
| FEZ1 | TOMM20 | NO | yeast 2-hybrid | 16169070 |
| FEZ1 | SAP30L | NO | in vitro;yeast 2-hybrid | 16484223 |
| FEZ1 | PTH | NO | yeast 2-hybrid | 16169070 |
| FEZ1 | HTT | YES | in vitro;yeast 2-hybrid | 15383276 |
| FEZ1 | COL9A2 | YES | yeast 2-hybrid | 16169070 |
Related other genetic factors
Gene related SNPs (count: 30)
Literature-origin SNPs (count: 11)
| rs_ID | Location | Functional Annotation | No. of Studies (Positive/Negative/Trend)  |
|---|---|---|---|
| rs2907228 | chr16:21931357 - 21931357(1) | 1(0/1/0) | |
| rs12223186 | chr11:125461743 - 125461743(1) | downstream_gene_variant; intron_variant; non_coding_transcript_variant | 1(0/1/0) |
| rs2241514 | chr11:125456130 - 125456130(1) | downstream_gene_variant; intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant | 2(0/2/0) |
| rs559668 | chr11:125487880 - 125487880(1) | downstream_gene_variant; intron_variant; non_coding_transcript_variant | 1(0/1/0) |
| rs597570 | chr11:125481576 - 125481576(1) | missense_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant | 2(0/2/0) |
| rs10893380 | chr11:125441778 - 125441778(1) | downstream_gene_variant | 1(0/1/0) |
| rs559688 | chr6:91712240 - 91712240(1) | 1(0/1/0) | |
| rs1365410 | chr11:125469216 - 125469216(1) | intron_variant; non_coding_transcript_variant | 1(0/1/0) |
| rs2702009 | chr11:125494945 - 125494945(1) | intron_variant; non_coding_transcript_variant; upstream_gene_variant | 2(0/2/0) |
| rs3217293 | chr11:125463733 - 125463734(1) | intron_variant; non_coding_transcript_variant; upstream_gene_variant | 1(0/1/0) |
| rs10893385 | chr11:125479025 - 125479025(1) | intron_variant; non_coding_transcript_variant | 1(0/1/0) |
LD-proxies (count: 19)
| rs_ID | Literature-origin SNPs with LD | Location | Functional Annotation |
|---|---|---|---|
| rs12224788 | chr11:125459165 - 125459165(1) | downstream_gene_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant | |
| rs7103665 | chr11:125472998 - 125472998(1) | intron_variant; non_coding_transcript_variant | |
| rs6590145 | chr11:125448020 - 125448020(1) | downstream_gene_variant; intron_variant; non_coding_transcript_variant | |
| rs7930295 | chr11:125443703 - 125443703(1) | downstream_gene_variant | |
| rs6590146 | chr11:125479933 - 125479933(1) | intron_variant; non_coding_transcript_variant | |
| rs11220081 | chr11:125453646 - 125453646(1) | downstream_gene_variant; intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant | |
| rs582108 | chr11:125482690 - 125482690(1) | intron_variant; non_coding_transcript_variant; upstream_gene_variant | |
| rs485680 | chr11:125483385 - 125483385(1) | intron_variant; non_coding_transcript_variant; upstream_gene_variant | |
| rs618900 | chr11:125480634 - 125480634(1) | intron_variant; non_coding_transcript_variant | |
| rs11605207 | chr11:125493780 - 125493780(1) | intron_variant; non_coding_transcript_variant; upstream_gene_variant | |
| rs11220099 | chr11:125495389 - 125495389(1) | 5_prime_UTR_variant; intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; splice_region_variant | |
| rs668593 | chr11:125484333 - 125484333(1) | downstream_gene_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant | |
| rs620475 | chr11:125486999 - 125486999(1) | downstream_gene_variant; intron_variant; non_coding_transcript_variant | |
| rs3016282 | chr11:125483039 - 125483039(1) | intron_variant; non_coding_transcript_variant; upstream_gene_variant | |
| rs669052 | chr11:125472234 - 125472234(1) | intron_variant; non_coding_transcript_variant | |
| rs2849222 | chr11:125483593 - 125483593(1) | intron_variant; non_coding_transcript_variant; upstream_gene_variant | |
| rs2702010 | chr11:125492831 - 125492831(1) | intron_variant; non_coding_transcript_variant; upstream_gene_variant | |
| rs2845846 | chr11:125485142 - 125485142(1) | downstream_gene_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant | |
| rs1783926 | chr11:125490740 - 125490740(1) | intron_variant; non_coding_transcript_variant; upstream_gene_variant |
Gene related CNVs (count: 0)
Gene related other variants (count: 3)
| Variant Name | Variant Type | Location in Gene | No. of Studies (Positive/Negative/Trend) |
|---|---|---|---|
| FEZ1_IVS3+2509C>T | point mutation | 1 (0/1/0) | |
| FEZ1_IVS9+66A>T | point mutation | 1 (0/1/0) | |
| FEZ1_IVS4+1077T>C | point mutation | 1 (0/1/0) |
Gene related regions (count: 1)
Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ
Overlap with SZ from cross-disorder studies (count: 2)
| Reference | Description | Result Category |
|---|---|---|
| 16936715 | No association to schizophrenia was found for any of the nine markers typed in these populations at the allelic or the genotypic level. Additionally no association was found in either population between specific haplotypes and any of the psychiatric disorders. Variation at the FEZ1 locus does not play a significant role in the etiology of schizophrenia in North American Caucasian or African American populations. | Negative |
| 15522253 | A modest association between FEZ1 and schizophrenia suggests that this gene and the DISC1-mediated molecular pathway might play roles in the development of schizophrenia, with FEZ1 affecting only a small subset of Japanese schizophrenia patients. | Positive |
Overlap with SZ from candidate gene intersection analysis (count: 5)
Gene relationship with MDD
View in gBrowse
Region: chr11:125445745..125496317 View in gBrowse
Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Acknowledgements
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Last update: March 31, 2016