Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	CRH
Symbol Alias	CRF, CRH1
Approved Name	corticotropin releasing hormone
Name Alias	corticotropin-releasing factor, "corticoliberin"
Location	8q13
Position	chr8:66176382-66178725, -1
External Links	HGNC: 2355 Entrez Gene: 1392 Ensembl: ENSG00000147571 UCSC: uc003xvy.2
No. of Studies	2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Gratacos, M.,2009	SNP: rs6999100	Nominal associations with bipolar disorder was observed.	Positive	Comment on Study
Alda, M.,2000	Other variant: CRH_polymorphisms	In conclusion, our study does not support the hypothesis that genes coding for CRH or PENK contribute to the genetic susceptibility to bipolar disorder.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 64)

GO terms by PBA (count: 5)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006954	inflammatory response	biological process	IDA[18559919]	23
GO:0005179	hormone activity	molecular function	TAS[7585095]	12
GO:0007565	female pregnancy	biological process	IDA[18559919]	15
GO:0005102	receptor binding	molecular function	TAS[7477348]	37
GO:0007268	synaptic transmission	biological process	TAS[7477348]	116

GO terms by database search (count: 59)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007616	long-term memory	biological process	IEA	9
GO:0005576	extracellular region	cellular component	TAS	97
GO:0030324	lung development	biological process	IEA	9
GO:0030325	adrenal gland development	biological process	IEA	5
GO:0050801	ion homeostasis	biological process	IEA	1
GO:0042322	negative regulation of circadian sleep/wake cycle, REM sleep	biological process	NAS[18329818]	1
GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	biological process	IEA	4
GO:0051431	corticotropin-releasing hormone receptor 2 binding	molecular function	IEA	1
GO:0032811	negative regulation of epinephrine secretion	biological process	IEA	4
GO:0005737	cytoplasm	cellular component	IEA	322
GO:0043204	perikaryon	cellular component	IEA	17
GO:0045472	response to ether	biological process	IEA	2
GO:0016101	diterpenoid metabolic process	biological process	IEA	2
GO:0006704	glucocorticoid biosynthetic process	biological process	IEA	1
GO:0045471	response to ethanol	biological process	IEA	24
GO:0008306	associative learning	biological process	IEA	8
GO:0051602	response to electrical stimulus	biological process	IEA	11
GO:0043196	varicosity	cellular component	IEA	2
GO:0030819	positive regulation of cAMP biosynthetic process	biological process	IEA	5
GO:0042493	response to drug	biological process	IEA	57
GO:0007611	learning or memory	biological process	TAS[7477348]	13
GO:0071314	cellular response to cocaine	biological process	IEA	2
GO:0014062	regulation of serotonin secretion	biological process	IEA	2
GO:0007631	feeding behavior	biological process	IEA	12
GO:0060456	positive regulation of digestive system process	biological process	IEA	1
GO:0035902	response to immobilization stress	biological process	IEA	5
GO:0005615	extracellular space	cellular component	IDA[18559919]	85
GO:0001963	synaptic transmission, dopaminergic	biological process	IDA[12895416]	8
GO:0035641	locomotory exploration behavior	biological process	IEA	4
GO:0010841	positive regulation of circadian sleep/wake cycle, wakefulness	biological process	NAS[18329818]	1
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity	biological process	IDA[12895416]	6
GO:0051461	positive regulation of corticotropin secretion	biological process	IEA	1
GO:0033685	negative regulation of luteinizing hormone secretion	biological process	IEA	1
GO:0005184	neuropeptide hormone activity	molecular function	TAS[7867564]	8
GO:0060548	negative regulation of cell death	biological process	IEA	5
GO:0021854	hypothalamus development	biological process	IEA	3
GO:0070093	negative regulation of glucagon secretion	biological process	IEA	2
GO:2000987	positive regulation of behavioral fear response	biological process	IEA	2
GO:0051464	positive regulation of cortisol secretion	biological process	IDA[18329818]	1
GO:0071549	cellular response to dexamethasone stimulus	biological process	IEA	4
GO:0051430	corticotropin-releasing hormone receptor 1 binding	molecular function	IEA	2
GO:0010942	positive regulation of cell death	biological process	IEA	1
GO:0001934	positive regulation of protein phosphorylation	biological process	IEA	15
GO:0045776	negative regulation of blood pressure	biological process	IEA	10
GO:2000854	positive regulation of corticosterone secretion	biological process	IEA	1
GO:0043627	response to estrogen	biological process	IEA	4
GO:0007567	parturition	biological process	TAS[7585095]	3
GO:0048265	response to pain	biological process	IEA	8
GO:0090280	positive regulation of calcium ion import	biological process	IEA	3
GO:0060291	long-term synaptic potentiation	biological process	IEA	14
GO:0010629	negative regulation of gene expression	biological process	IEA	12
GO:0017045	corticotropin-releasing hormone activity	molecular function	IEA	1
GO:0008284	positive regulation of cell proliferation	biological process	IEA	44
GO:0007165	signal transduction	biological process	TAS[7867564]	136
GO:0008628	hormone-mediated apoptotic signaling pathway	biological process	IEA	2
GO:0005515	protein binding	molecular function	IPI[18234674]	563
GO:0010628	positive regulation of gene expression	biological process	IEA	23
GO:0051412	response to corticosterone	biological process	IEA	9
GO:0010700	negative regulation of norepinephrine secretion	biological process	IEA	3

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04730	Long-term depression	15

KEGG pathways by database search (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
CRH	CRHR2	YES	in vitro;in vivo	8243338

Related other genetic factors

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs6999100	chr8:66170497 - 66170497(1)	intron_variant; non_coding_transcript_variant	1(1/0/0)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
CRH_polymorphisms	VNTR		1 (0/1/0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
8q12.1-q22.1	chr8:54600000-97900000	1 (1/0/0)
8q13	chr8:65100000-72000000	4 (0/4/0)
8p11.21-q21.13	chr8:39900000-83500000	1 (1/0/0)
Chr 8	chr8:0-145138636	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr8:66176382..66178725 View in gBrowse