Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

ADD to My Gene Set

Comment on Gene

View All Comments on Gene

Basic Info

Approved Symbol	SLC17A3
Symbol Alias	NPT4
Approved Name	solute carrier family 17 (organic anion transporter), member 3
Previous Name	solute carrier family 17 (sodium phosphate), member 3
Location	6p22.2
Position	chr6:25833066-25882286, -1
External Links	HGNC: 10931 Entrez Gene: 10786 Ensembl: ENSG00000124564 UCSC: uc003nfk.4
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Johnson, C.,2009		Monte-Carlo Simulation P-value = 0.0015. One of Genes That Harbor Overlapping Clusters of 4 Nominally Positive SNPs Whose Allele Frequencies Distinguish Individuals With Bipolar Disorder From Controls With P<0.05 Nominal Significance From at Least Three of the Four Samples in This Analysis	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 29)

GO terms by PBA (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0005887	integral component of plasma membrane	cellular component	IDA[20810651]	158

GO terms by database search (count: 27)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0015711	organic anion transport	biological process	IDA[20810651]	2
GO:0031526	brush border membrane	cellular component	ISS	5
GO:0005436	sodium:phosphate symporter activity	molecular function	ISS	2
GO:0015760	glucose-6-phosphate transport	biological process	TAS[15505377]	1
GO:0016324	apical plasma membrane	cellular component	IDA[20810651]	24
GO:0005737	cytoplasm	cellular component	IDA[20810651]	322
GO:0015238	drug transmembrane transporter activity	molecular function	IDA[20810651]	2
GO:0015562	efflux transmembrane transporter activity	molecular function	IDA[20810651]	1
GO:1903825	organic acid transmembrane transport	biological process	IDA[20810651]	1
GO:0005789	endoplasmic reticulum membrane	cellular component	IDA[15505377]; TAS	52
GO:0048471	perinuclear region of cytoplasm	cellular component	IDA[15505377]	50
GO:0008514	organic anion transmembrane transporter activity	molecular function	IDA[20810651]	2
GO:0046415	urate metabolic process	biological process	IMP[18834626]	2
GO:0055085	transmembrane transport	biological process	TAS	77
GO:1903959	regulation of anion transmembrane transport	biological process	IDA[20810651]	1
GO:0035725	sodium ion transmembrane transport	biological process	ISS	8
GO:0006814	sodium ion transport	biological process	ISS	6
GO:0008308	voltage-gated anion channel activity	molecular function	IDA[20810651]	1
GO:0006817	phosphate ion transport	biological process	ISS	1
GO:0034220	ion transmembrane transport	biological process	TAS	50
GO:0006855	drug transmembrane transport	biological process	IDA[20810651]	3
GO:0019534	toxin transporter activity	molecular function	IDA[20810651]	2
GO:0015143	urate transmembrane transporter activity	molecular function	IDA[20810651]	1
GO:1901998	toxin transport	biological process	IDA[20810651]	4
GO:0015747	urate transport	biological process	IDA[20810651]	1
GO:0015893	drug transport	biological process	IDA[20810651]	1
GO:0035435	phosphate ion transmembrane transport	biological process	ISS	2

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 6	chr6:0-170805979	3 (0/3/0)
6p22	chr6:15200000-30500000	1 (0/1/0)
6p22.2	chr6:25200000-27100000	1 (0/1/0)
6p23-p21.1	chr6:13400000-46200000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr6:25833066..25882286 View in gBrowse