Gene Report

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Basic Info

Approved Symbol	RGS5
Approved Name	regulator of G-protein signaling 5
Previous Name	regulator of G-protein signalling 5
Location	1q23.1
Position	chr1:163111121-163321791, -1
External Links	HGNC: 10001 Entrez Gene: 8490 Ensembl: ENSG00000143248 UCSC: uc001gcn.3
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Smith, E. N.,2009	SNP: rs4657247	SNPs with the strongest statistical evidence for genetic background effects included rs11208285 in ROR1 at 1p31.3 (P=1.4E-06), rs4657247 in RGS5 at 1q23.3 (P=4.1E-06), and rs7078071 in BTBD16 at 10q26.13 (P=4.5E-06).	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	IBA	360

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0038032	termination of G-protein coupled receptor signaling pathway	biological process	IEA	7
GO:0005096	GTPase activator activity	molecular function	IBA	19
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway	biological process	TAS[10471929]	5
GO:0007165	signal transduction	biological process	IEA	136
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0043547	positive regulation of GTPase activity	biological process	IBA; TAS[10471929]	30

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
RGS5	GNAQ	NO	in vivo	11253162
RGS5	GNAO1	NO	in vitro;in vivo	9079700
RGS5	GNAI3	NO	in vitro	9079700

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs4657247	chr1:163182107 - 163182107(1)	intron_variant; non_coding_transcript_variant	1(0/0/1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
1q23	chr1:156600000-165500000	1 (0/1/0)
1p32.1-q31.1	chr1:58500000-190800000	1 (0/1/0)
1q23.3	chr1:160500000-165500000	1 (0/0/1)
Chr 1	chr1:0-248956422	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr1:163111121..163321791 View in gBrowse