Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	DAB1
Approved Name	Dab, reelin signal transducer, homolog 1 (Drosophila)
Previous Name	disabled (Drosophila) homolog 1, "disabled homolog 1 (Drosophila)", "Dab, reelin signal transducer, homolog 1 (Drosophila)", "Dab reelin signal transducer 1"
Location	1p32-p31
Position	chr1:56994778-58546734, -1
External Links	HGNC: 2661 Entrez Gene: 1600 Ensembl: ENSG00000173406 UCSC: uc001cys.1
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Kuo, P. H., 2014		No significant association was observed.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 28)

GO terms by PBA (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016020	membrane	cellular component	IEA	137

GO terms by database search (count: 27)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0045860	positive regulation of protein kinase activity	biological process	IEA	8
GO:0048471	perinuclear region of cytoplasm	cellular component	IEA	50
GO:0021942	radial glia guided migration of Purkinje cell	biological process	IEA	1
GO:0021799	cerebral cortex radially oriented cell migration	biological process	IEA	5
GO:0043025	neuronal cell body	cellular component	IEA	50
GO:0021813	cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration	biological process	IEA	1
GO:0048712	negative regulation of astrocyte differentiation	biological process	IEA	5
GO:0097477	lateral motor column neuron migration	biological process	IEA	2
GO:0005829	cytosol	cellular component	IEA	223
GO:0021517	ventral spinal cord development	biological process	IEA	3
GO:0051645	Golgi localization	biological process	IEA	1
GO:0005515	protein binding	molecular function	IPI[25416956]	563
GO:0007494	midgut development	biological process	IEA	1
GO:0014069	postsynaptic density	cellular component	IEA	26
GO:0043548	phosphatidylinositol 3-kinase binding	molecular function	IEA	4
GO:0045177	apical part of cell	cellular component	IEA	13
GO:0046426	negative regulation of JAK-STAT cascade	biological process	IEA	1
GO:0043005	neuron projection	cellular component	IEA	38
GO:0016358	dendrite development	biological process	IEA	8
GO:0021589	cerebellum structural organization	biological process	IEA	2
GO:0042493	response to drug	biological process	IEA	57
GO:0007264	small GTPase mediated signal transduction	biological process	IEA	18
GO:0050771	negative regulation of axonogenesis	biological process	IEA	5
GO:0007628	adult walking behavior	biological process	IEA	9
GO:0007162	negative regulation of cell adhesion	biological process	IEA	5
GO:0045666	positive regulation of neuron differentiation	biological process	IEA	8
GO:0005903	brush border	cellular component	IEA	2

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 1)

BioCarta pathways by PBA (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
reelinPathway	Reelin Signaling Pathway	4

BioCarta pathways by database search (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 21)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
DAB1	CRK	NO	in vitro	15062102
DAB1	PAFAH1B1	NO	in vivo	14578885
DAB1	VLDLR	NO	in vitro	10380922
DAB1	CRKL	NO	in vitro	15062102
DAB1	PTPN11	NO	in vitro	15062102
DAB1	ITGB2	YES	in vitro	12606711
DAB1	CDK5	NO	in vitro;in vivo	12077184
DAB1	APLP2	NO	in vitro	10460257
DAB1	DAB2IP	NO	in vitro;in vivo	11812785
DAB1	LRP1	NO	in vitro;in vivo;yeast 2-hybrid	10827173
DAB1	APLP1	NO	in vitro;in vivo;yeast 2-hybrid	10460257
DAB1	LRP2	NO	in vitro;yeast 2-hybrid	10827173 , 9837937
DAB1	APP	NO	in vitro	10460257 , 9837937
DAB1	ITGB7	NO	in vitro	12606711
DAB1	SIAH1	NO	in vitro;in vivo;yeast 2-hybrid	12646221
DAB1	ITGB3	NO	in vitro	12606711
DAB1	RELN	YES	in vivo	11137154
DAB1	LDLR	NO	in vitro;in vivo	10380922 , 9837937
DAB1	SRC	NO	in vitro;in vivo	15062102 , 11279201 , 10959835
DAB1	ITGB5	NO	in vitro	12606711
DAB1	PCDH18	NO	in vitro;in vivo;yeast 2-hybrid	11716507

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 1	chr1:0-248956422	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr1:56994778..58546734 View in gBrowse