Gene Report

Basic Info
Approved Symbol SLC1A2
Symbol Alias GLT-1, EAAT2
Approved Name solute carrier family 1 (glial high affinity glutamate transporter), member 2
Location 11p13-p12
Position chr11:35251206-35420063, -1
External Links HGNC: 10940
Entrez Gene: 6506
Ensembl: ENSG00000110436
UCSC: uc001mwd.3
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Fiorentino, A., 2014 SNP: rs77619780, rs11033118, rs145827578, rs56205617, rs199599866, rs147294857, rs3812779
Other variant: SLC1A2_Chr1:35441380_G/C, SLC1A2_Chr1:35440927_A/G, SLC1A2_Chr1:35440635_G/A, SLC1A2_Chr1:35440563_C/G, SLC1A2_Chr1:35344202_G/T, SLC1A2_Chr1:35339061_C/T, SLC1A2_Chr1:35282452_C/T, SLC1A2_Chr1:35279202_A/G
Combined analysis of the recurrent-case-only missense variants and of the case-only missense and 5-UTR variants showed nominal evidence for association with the combined diseases Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 24)

GO terms by PBA (count: 5)

GO terms by database search (count: 19)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Related other genetic factors
Gene related SNPs (count: 16)

Literature-origin SNPs (count: 8)

LD-proxies (count: 8)

Gene related CNVs (count: 0)

Gene related other variants (count: 23)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 2)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 5)

View in gBrowse

Region: chr11:35251206..35420063 View in gBrowse
View in gBrowse