Gene Report

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Basic Info

Approved Symbol	KCTD1
Previous Symbol	C18orf5
Approved Name	potassium channel tetramerization domain containing 1
Previous Name	potassium channel tetramerisation domain containing 1
Location	18q11.2
Position	chr18:26454910-26657401, -1
External Links	HGNC: 18249 Entrez Gene: 284252 Ensembl: ENSG00000134504 UCSC: uc010xbj.4
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Johnson, C.,2009		Monte-Carlo Simulation P-value = 0.0029. One of Genes That Harbor Overlapping Clusters of 4 Nominally Positive SNPs Whose Allele Frequencies Distinguish Individuals With Bipolar Disorder From Controls With P<0.05 Nominal Significance From at Least Three of the Four Samples in This Analysis	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IDA[19115315]	283
GO:0003714	transcription corepressor activity	molecular function	IDA[19115315]	21

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0051260	protein homooligomerization	biological process	IEA	13
GO:0008134	transcription factor binding	molecular function	IPI[19115315]	28
GO:0045892	negative regulation of transcription, DNA-templated	biological process	IDA[19115315]	43
GO:0005515	protein binding	molecular function	IPI[25416956]	563
GO:0006351	transcription, DNA-templated	biological process	IEA	103

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
18p11-q12.3	chr18:0-45900000	1 (0/0/1)
18q	chr18:18500000-80373285	1 (0/1/0)
Chr 18	chr18:0-80373285	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr18:26454910..26657401 View in gBrowse