Gene Report

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Basic Info

Approved Symbol	HSF2
Approved Name	heat shock transcription factor 2
Location	6q22
Position	chr6:122399546-122433119, 1
External Links	HGNC: 5225 Entrez Gene: 3298 Ensembl: ENSG00000025156 UCSC: uc003pyu.2
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Fan, J., 2010		For gene-based test, P-value = 0.007 in STEP1; P-value = 0.93 in NIMH; P-value = 0.043 in STEP1 and NIMH. nominally significant in STEP1 sample and pooled sample, but not survive Bonferroni correction test.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 12)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IEA	283
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	TAS[1871106]	66

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005737	cytoplasm	cellular component	IEA	322
GO:0007283	spermatogenesis	biological process	IEA	29
GO:0001162	RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding	molecular function	IDA[10561509]	1
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	molecular function	IDA[10561509]	5
GO:0003713	transcription coactivator activity	molecular function	TAS[1871106]	22
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IDA[10561509]	91
GO:0042803	protein homodimerization activity	molecular function	IEA	71
GO:0005515	protein binding	molecular function	IPI[25416956]	563
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	molecular function	IDA[10561509]	10
GO:0006366	transcription from RNA polymerase II promoter	biological process	TAS[1871106]	31

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 8)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
HSF2	NUP62	YES	in vitro;yeast 2-hybrid	9367915
HSF2	HSF2BP	NO	in vitro;in vivo;yeast 2-hybrid	9651507
HSF2	UBE2I	NO	in vivo	11278381
HSF2	NCAPG	NO	in vitro;yeast 2-hybrid	15662014
HSF2	HSF1	NO	in vitro;in vivo	12813038
HSF2	SUMO3	NO	in vitro	16428449
HSF2	PPP2R1A	NO	in vitro;in vivo;yeast 2-hybrid	10224043
HSF2	SUMO2	NO	in vitro	16428449

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 6	chr6:0-170805979	3 (0/3/0)
6q14-22	chr6:75200000-130000000	1 (0/0/1)
6q22.1-6q22.33	chr6:114200000-130000000	1 (0/1/0)
6q21-22	chr6:105000000-130000000	1 (0/0/1)
6q22	chr6:114200000-130000000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr6:122399546..122433119 View in gBrowse