Gene Report

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Basic Info

Approved Symbol	TACC2
Symbol Alias	AZU-1
Approved Name	transforming, acidic coiled-coil containing protein 2
Location	10q26
Position	chr10:121989174-122254545, 1
External Links	HGNC: 11523 Entrez Gene: 10579 Ensembl: ENSG00000138162 UCSC: uc001lfv.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Johnson, C.,2009		Monte-Carlo Simulation P-value = 0.0014. One of Genes That Harbor Overlapping Clusters of 4 Nominally Positive SNPs Whose Allele Frequencies Distinguish Individuals With Bipolar Disorder From Controls With P<0.05 Nominal Significance From at Least Three of the Four Samples in This Analysis	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IDA	283
GO:0019904	protein domain specific binding	molecular function	IEA	24

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005815	microtubule organizing center	cellular component	IEA	10
GO:0000226	microtubule cytoskeleton organization	biological process	IBA	9
GO:0008283	cell proliferation	biological process	IBA	37
GO:0022008	neurogenesis	biological process	IEA	4
GO:0032886	regulation of microtubule-based process	biological process	IEA	4
GO:0030953	astral microtubule organization	biological process	IEA	2
GO:0035257	nuclear hormone receptor binding	molecular function	IDA[15207008]	5
GO:0015630	microtubule cytoskeleton	cellular component	IBA	12
GO:0005654	nucleoplasm	cellular component	IDA	163
GO:0005730	nucleolus	cellular component	IDA	28
GO:0022027	interkinetic nuclear migration	biological process	IEA	2
GO:0021987	cerebral cortex development	biological process	IBA	9
GO:0005737	cytoplasm	cellular component	IEA	322

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 9)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
TACC2	KAT2A	NO	in vitro;in vivo	14767476
TACC2	HMG20B	NO	yeast 2-hybrid	16169070
TACC2	SMARCB1	NO	in vivo	12620397
TACC2	RXRB	NO	in vitro	15207008
TACC2	YEATS4	NO	in vitro;in vivo	12620397
TACC2	AURKC	NO	yeast 2-hybrid	14602875
TACC2	KAT2B	NO	in vivo	14767476
TACC2	EP300	NO	in vivo	14767476
TACC2	CREBBP	YES	in vivo	14767476

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 10	chr10:0-133797422	3 (0/2/1)
10q25-q26	chr10:104000000-133797422	2 (0/0/2)
10q26	chr10:117300000-133797422	3 (0/1/2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	ID in SZGene	Result Category
18813210	760	Positive

Gene relationship with MDD

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Region: chr10:121989174..122254545 View in gBrowse