Gene Report

Approved Symbol	DGKH
Symbol Alias	DGKeta
Approved Name	diacylglycerol kinase, eta
Location	13q13.3
Position	chr13:42040036-42256578, 1
External Links	HGNC: 2854 Entrez Gene: 160851 Ensembl: ENSG00000102780 UCSC: uc001uyl.2
No. of Studies	6 (Positive: 3; Negative: 3; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Squassina, A.,2009	SNP: rs1012053, rs1170191, rs9315885 Haplotype: rs9315885 - rs1012053 - rs1170191(C-A-C), rs9315885 - rs1012053 - rs1170191(C-C-A), rs9315885 - rs1012053 - rs1170191(T-A-A), rs9315885 - rs1012053 - rs1170191(T-A-C)	Our study does not replicate the single-marker association reported by Baum et al.However, the significant association for haplotype H2 may reflect the presence of other markers in LD with the block.The association for a DGKH haplotype reported in our sample, although intriguing, must be interpreted with caution and further studies need to be performed to clarify the role of DGKH in BD.	Positive	Comment on Study
Ollila, H. M.,2009	SNP: rs1170191, rs9315885	It showed no evidence for association with BPI in our study.	Negative	Comment on Study
Yosifova, A.,2009	SNP: rs1012053, rs1170191, rs9315897, rs9525570	No SNP of this gene had significant association with BD in our population.	Negative	Comment on Study
Tesli, M.,2009	SNP: rs1033951, rs11616202, rs11617266, rs1170098, rs1170101, rs1170183, rs1170192, rs12584909, rs12876965, rs17062754, rs17519598, rs17598799, rs180870, rs2148656, rs2324890, rs2767388, rs2767390, rs347382, rs347383, rs347405, rs347416, rs4598803, rs545602, rs6561029, rs6561030, rs681657, rs686810, rs716934, rs7981733, rs7984523, rs9533002, rs9533007, rs9533040, rs9562377, rs9562385, rs9594670	We found no significant association after multiple-testing correction between any of these SNPs and BD in our sample. Thus, it is unlikely that these genetic variations confer susceptibility to BD in this large Scandinavian sample.	Negative	Comment on Study
Zeng, Z.,2011	SNP: rs1012053, rs1170098, rs1170099, rs1170191, rs2122246, rs347387, rs716934, rs9315885, rs9315897, rs9532988, rs9533042, rs9566931, rs9566940 Haplotype: rs1170099 - rs9566940(A-C), rs1170099 - rs9566940(A-T), rs1170099 - rs9566940(G-T), rs716934 - rs9566931 - rs9315897 - rs2122246(A-A-C-G), rs716934 - rs9566931 - rs9315897 - rs2122246(A-A-T-G), rs716934 - rs9566931 - rs9315897 - rs2122246(T-A-T-A), rs716934 - rs9566931 - rs9315897 - rs2122246(T-A-T-G), rs716934 - rs9566931 - rs9315897 - rs2122246(T-G-T-G), rs9315885 - rs9532988 - rs1012053(C-A-A), rs9315885 - rs9532988 - rs1012053(C-A-C), rs9315885 - rs9532988 - rs1012053(T-A-A), rs9315885 - rs9532988 - rs1012053(T-G-A)	In summary, our results support DGKH as shared risk factor of BPD and SCZ in the Chinese Han population.	Positive	Comment on Study
Takata, A.,2011(a)	SNP: rs1012053, rs1170191, rs1170195, rs17646069, rs35776153, rs9315885, rs9315897, rs9525570	Although the association was not strong, the result of this study would support the association between DGKH and BD.	Positive	Comment on Study

Region: chr13:42040036..42256578 View in gBrowse