Search SNP
Search Gene
Search CNV
Search Haplotype
Search Other Variant
Search Region
Search Pathway
Search Study
GO Report
Basic Info
| ID | GO:0007417 |
|---|---|
| Name | central nervous system development |
| Type | biological process |
| No. of Genes in BDgene | 21 |
| Source | Pathway by PBA |
PBA Result
| Pathway Name in Paper | Source | Reference | Data Set | Tool | Result Parameters | Result Link |
|---|---|---|---|---|---|---|
| CENTRAL NERVOUS SYSTEM DEVELOPMENT | i-GSEA analysis | From NIMH | Pritzker Neuropsychiatric Disorders Research Consortium | i-GSEA by using i-GSEA4GWAS | P-value< 0.001, FDR=0.040666666 | Link in i-GSEA4GWAS |
| GO: 0007417: central nervous system development | PBA paper | Askland, K.,2009 | NIMH | Fisher's exact test | Results given for gene sets with P < 0.01 from the NIMH PBA-BP data |
GO related genes in BDgene (count: 21)
| Approved Symbol | Approved Name | Location | No. of Studies (Positive/Negative/Trend)  |
Evidence[PMID] |
|---|---|---|---|---|
| GPR124 | adhesion G protein-coupled receptor A2 | 8p11.22 | 0 | ISS |
| TPP1 | tripeptidyl peptidase I | 11p15.4 | 1(1/0/0) | IBA |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 3p12.3 | 1(0/1/0) | NAS[9458045] |
| NPTX1 | neuronal pentraxin I | 17q25.3 | 2(1/1/0) | TAS[8884281] |
| XRCC4 | X-ray repair complementing defective repair in Chinese hamster cells 4 | 5q14.2 | 1(0/1/0) | IEA |
| NPAS2 | neuronal PAS domain protein 2 | 2q11.2 | 5(3/2/0) | TAS[9012850] |
| RELN | reelin | 7q22 | 3(1/2/0) | ISS |
| PAX8 | paired box 8 | 2q13 | 1(0/0/1) | IEP[15494458] |
| NMUR2 | neuromedin U receptor 2 | 5q33.1 | 1(0/1/0) | IEP[10899166] |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | 6q21 | 1(1/0/0) | IBA |
| MBP | myelin basic protein | 18q23 | 1(1/0/0) | TAS[2434243] |
| POU6F2 | POU class 6 homeobox 2 | 7p14.1 | 1(1/0/0) | TAS[8601806] |
| GABRA4 | gamma-aminobutyric acid (GABA) A receptor, alpha 4 | 4p12 | 2(2/0/0) | IEA |
| PARK2 | parkin RBR E3 ubiquitin protein ligase | 6q25.2-q27 | 1(1/0/0) | TAS[9560156] |
| DRP2 | dystrophin related protein 2 | Xq22 | 1(1/0/0) | TAS[8640231] |
| S100B | S100 calcium binding protein B | 21q22.3 | 2(1/1/0) | TAS[8202493] |
| ARNT2 | aryl-hydrocarbon receptor nuclear translocator 2 | 15q25.1 | 1(0/1/0) | ISS |
| SNTG2 | syntrophin, gamma 2 | 2p25 | 1(0/0/1) | TAS[10747910] |
| NCAN | neurocan | 19p12 | 1(1/0/0) | IBA |
| PTPRZ1 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | 7q31.3 | 1(1/0/0) | TAS[8387522] |
| CNTN6 | contactin 6 | 3p26.3 | 1(1/0/0) | TAS[9486763] |