Gene Report

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Basic Info

Approved Symbol	TENM2
Previous Symbol	ODZ2
Symbol Alias	KIAA1127, Ten-M2
Approved Name	teneurin transmembrane protein 2
Previous Name	odz, odd Oz/ten-m homolog 2 (Drosophila)
Location	5q35
Position	chr5:167284799-168264157, 1
External Links	HGNC: 29943 Entrez Gene: 57451 Ensembl: ENSG00000145934 UCSC: uc010jjd.3
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Cruceanu, C., 2013	Other variant: ODZ2_Chr5:167627125_C/T	Rare variant was found within this gene.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 29)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0045202	synapse	cellular component	ISS	29
GO:0005102	receptor binding	molecular function	IDA[21724987]; IEA	37
GO:0005887	integral component of plasma membrane	cellular component	IEA	158
GO:0005634	nucleus	cellular component	ISS	283
GO:0007411	axon guidance	biological process	IDA[21724987]	60
GO:0045211	postsynaptic membrane	cellular component	ISS	68
GO:0005886	plasma membrane	cellular component	IDA[21724987]; ISS	360

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0042803	protein homodimerization activity	molecular function	ISS	71
GO:0030054	cell junction	cellular component	ISS	88
GO:0005515	protein binding	molecular function	IPI[21724987]	563
GO:0030425	dendrite	cellular component	ISS	65
GO:0005911	cell-cell junction	cellular component	IDA[21724987]	16
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	ISS	62
GO:0043005	neuron projection	cellular component	ISS	38
GO:0030175	filopodium	cellular component	ISS	5
GO:0043197	dendritic spine	cellular component	ISS	21
GO:0050839	cell adhesion molecule binding	molecular function	IDA[21724987]	6
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:0051491	positive regulation of filopodium assembly	biological process	ISS	1
GO:0005794	Golgi apparatus	cellular component	ISS	60
GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	biological process	IDA[21724987]	4
GO:0007165	signal transduction	biological process	IEA	136
GO:0035584	calcium-mediated signaling using intracellular calcium source	biological process	IDA[21724987]	4
GO:0016337	single organismal cell-cell adhesion	biological process	ISS	10
GO:0016605	PML body	cellular component	ISS	7
GO:0030426	growth cone	cellular component	ISS	22
GO:0005783	endoplasmic reticulum	cellular component	ISS	49
GO:0046982	protein heterodimerization activity	molecular function	ISS	42
GO:0097264	self proteolysis	biological process	IEA	2

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs2902101	chr5:167021674 - 167021674(1)		1(1/0/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
ODZ2_Chr5:167627125_C/T	Missense	Chr5:167627125	1 (0/0/1)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 5	chr5:0-181538259	3 (0/2/1)
5q33-34	chr5:150400000-169000000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr5:167284799..168264157 View in gBrowse