Gene Report

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Basic Info

Approved Symbol	SGCZ
Symbol Alias	ZSG1
Approved Name	sarcoglycan, zeta
Location	8p22
Position	chr8:14089864-15238339, -1
External Links	HGNC: 14075 Entrez Gene: 137868 Ensembl: ENSG00000185053 UCSC: uc003wwq.3
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Jamain, S., 2014	SNP: rs10096683	It showed nominal evidence for association with BD.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IEA	219

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016012	sarcoglycan complex	cellular component	TAS[17438352]	2
GO:0046716	muscle cell cellular homeostasis	biological process	TAS[17438352]	4
GO:0048738	cardiac muscle tissue development	biological process	IBA	4
GO:0042383	sarcolemma	cellular component	IBA	12
GO:0007517	muscle organ development	biological process	IBA	11
GO:0061024	membrane organization	biological process	TAS[17438352]	14
GO:0055001	muscle cell development	biological process	TAS[17438352]	2
GO:0060047	heart contraction	biological process	IBA	3
GO:0005737	cytoplasm	cellular component	IEA	322
GO:0005856	cytoskeleton	cellular component	IEA	30

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
SGCZ	DMD	NO	in vitro	12189167
SGCZ	SGCB	NO	in vitro	12189167

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs10096683	chr8:14304694 - 14304694(1)	intron_variant; upstream_gene_variant	1(0/0/1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
8p22	chr8:12800000-19200000	1 (0/0/1)
8pter-p22	chr8:0-19200000	1 (0/1/0)
Chr 8	chr8:0-145138636	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr8:14089864..15238339 View in gBrowse