Gene Report

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Basic Info

Approved Symbol	LRRC15
Symbol Alias	LIB
Approved Name	leucine rich repeat containing 15
Location	3q29
Position	chr3:194355247-194369743, -1
External Links	HGNC: 20818 Entrez Gene: 131578 Ensembl: ENSG00000172061 UCSC: uc003ftu.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Schosser, A.,2011	SNP: rs13070515 Haplotype: rs4974539 - rs13070515()	No significant association was observed.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 8)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IEA	219

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0046813	receptor-mediated virion attachment to host cell	biological process	IMP[18385238]	1
GO:0001968	fibronectin binding	molecular function	IDA[16098915]	1
GO:0043236	laminin binding	molecular function	IDA[16098915]	2
GO:0030335	positive regulation of cell migration	biological process	IMP[16098915]	16
GO:0090005	negative regulation of establishment of protein localization to plasma membrane	biological process	IMP[18385238]	2
GO:0005518	collagen binding	molecular function	IDA[16098915]	4
GO:0070062	extracellular vesicular exosome	cellular component	IDA[19056867]	176

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 18)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs13070515	chr3:194360187 - 194360187(1)	missense_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs923934	chr3:194361171 - 194361171(1)	intron_variant
rs923933	chr3:194361226 - 194361226(1)	intron_variant
rs9682541	chr3:194359967 - 194359967(1)	missense_variant; synonymous_variant
rs13060627	chr3:194360254 - 194360254(1)	missense_variant
rs2898620	chr3:194364574 - 194364574(1)	intron_variant
rs4974536	chr3:194367225 - 194367225(1)	intron_variant
rs6797069	chr3:194361571 - 194361571(1)	intron_variant
rs923932	chr3:194364135 - 194364135(1)	intron_variant
rs6792027	chr3:194351840 - 194351840(1)	downstream_gene_variant; upstream_gene_variant
rs8513	chr3:194355482 - 194355482(1)	3_prime_UTR_variant; downstream_gene_variant; upstream_gene_variant
rs6789870	chr3:194359182 - 194359182(1)	3_prime_UTR_variant
rs9682540	chr3:194359919 - 194359919(1)	synonymous_variant
rs12636143	chr3:194358019 - 194358019(1)	3_prime_UTR_variant
rs6789434	chr3:194358830 - 194358830(1)	3_prime_UTR_variant
rs6802684	chr3:194368411 - 194368411(1)	intron_variant
rs10933666	chr3:194367770 - 194367770(1)	intron_variant
rs6762637	chr3:194368613 - 194368613(1)	intron_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 3	chr3:0-198295559	2 (0/2/0)
3q29	chr3:192600000-198295559	2 (1/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr3:194355247..194369743 View in gBrowse