Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	TGM2
Symbol Alias	TGC
Approved Name	transglutaminase 2
Previous Name	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)
Name Alias	C polypeptide, protein-glutamine-gamma-glutamyltransferase
Location	20q12
Position	chr20:38127387-38166578, -1
External Links	HGNC: 11778 Entrez Gene: 7052 Ensembl: ENSG00000198959 UCSC: uc002xhr.4
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Graae, L.,2012	SNP: rs6023059	Supportive evidence for significant association findings was also observed.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 24)

GO terms by PBA (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0019904	protein domain specific binding	molecular function	IEA	24

GO terms by database search (count: 23)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0051561	positive regulation of mitochondrial calcium ion concentration	biological process	IMP[24349085]	1
GO:0050729	positive regulation of inflammatory response	biological process	IEA	6
GO:0001974	blood vessel remodeling	biological process	IEA	8
GO:0005525	GTP binding	molecular function	IEA	20
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	biological process	IEA	14
GO:0060445	branching involved in salivary gland morphogenesis	biological process	IEA	3
GO:0005829	cytosol	cellular component	IDA[24349085]	223
GO:0003810	protein-glutamine gamma-glutamyltransferase activity	molecular function	IMP[24349085]; ISS	1
GO:0051260	protein homooligomerization	biological process	IEA	13
GO:0043065	positive regulation of apoptotic process	biological process	IMP[24349085]	25
GO:0048661	positive regulation of smooth muscle cell proliferation	biological process	IEA	11
GO:0005739	mitochondrion	cellular component	IDA[24349085]	75
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway	biological process	IEA	6
GO:0031226	intrinsic component of plasma membrane	cellular component	IDA[2578891]; IMP[8105889]	3
GO:0018153	isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine	biological process	IEA	1
GO:0045785	positive regulation of cell adhesion	biological process	ISS	4
GO:0005515	protein binding	molecular function	IPI[16301118]	563
GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration	biological process	IMP[24349085]	1
GO:0046872	metal ion binding	molecular function	IEA	115
GO:0043277	apoptotic cell clearance	biological process	IDA[19628791]	3
GO:0005925	focal adhesion	cellular component	IDA[21423176]	32
GO:0060662	salivary gland cavitation	biological process	IEA	2
GO:0070062	extracellular vesicular exosome	cellular component	IDA[19056867]	176

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa05040	Huntington's disease	6

Gene related BioCarta pathways (count: 1)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
plcdPathway	Phospholipase C d1 in phospholipid associated cell signaling	2

Gene related interactors from protein-protein interactions data in HPRD (count: 27)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
TGM2	S100A7	NO	in vitro	11258932
TGM2	SMAD3	NO	yeast 2-hybrid	15231748
TGM2	ITGB1	NO	in vivo	10684262
TGM2	SERPINF2	NO	in vitro	10963790 , 10958788
TGM2	TUBB	YES	in vitro;in vivo	9973324
TGM2	TMSB4X	NO	in vivo	10611475
TGM2	HIST2H2BE	NO	in vitro;in vivo	9973324
TGM2	GSTP1	NO	in vivo	9973324
TGM2	HTT	YES	in vivo	11442349
TGM2	KPNA3	NO	in vivo;yeast 2-hybrid	10100610
TGM2	HIST1H2BG	NO	in vivo	9973324
TGM2	EIF5A	NO	in vitro;in vivo	9442029
TGM2	SPARC	NO	in vitro	7730416
TGM2	CASP3	NO	in vitro	10556977
TGM2	PPHLN1	NO	in vitro	12853457
TGM2	SMAD2	NO	yeast 2-hybrid	15231748
TGM2	ITGB3	NO	in vitro;in vivo	10684262
TGM2	ACTB	NO	in vitro;in vivo	9252372
TGM2	MAP3K12	NO	in vitro	10922377
TGM2	FN1	NO	in vitro	11829448 , 11686302
TGM2	ALDOA	NO	in vitro	1353685
TGM2	RELA	NO	in vivo	16951195
TGM2	PLCD1	NO	in vitro;in vivo	10518533 , 9512491
TGM2	LTBP1	NO	in vitro	9060478
TGM2	RB1	NO	in vitro	9315663
TGM2	RHOA	NO	in vivo	11350930
TGM2	KPNA4	NO	in vitro;in vivo;yeast 2-hybrid	10100610

Related other genetic factors

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs6023059	chr20:38109369 - 38109369(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant	1(1/0/0)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 20	chr20:0-64444167	4 (0/3/1)
20p11-q13	chr20:17900000-64444167	1 (1/0/0)
20q11	chr20:28100000-39000000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 2)

Reference	ID in SZGene	Result Category
18561261	719	Positive
20926141	719	Positive

Gene relationship with MDD

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Region: chr20:38127387..38166578 View in gBrowse