Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	TGM2
Symbol Alias	TGC
Approved Name	transglutaminase 2
Previous Name	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)
Name Alias	C polypeptide, protein-glutamine-gamma-glutamyltransferase
Location	20q12
Position	chr20:38127387-38166578, -1
External Links	HGNC: 11778 Entrez Gene: 7052 Ensembl: ENSG00000198959 UCSC: uc002xhr.4
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Graae, L.,2012	SNP: rs6023059	Supportive evidence for significant association findings was also observed.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 24)

GO terms by PBA (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0019904	protein domain specific binding	molecular function	IEA	24

GO terms by database search (count: 23)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0051561	positive regulation of mitochondrial calcium ion concentration	biological process	IMP[24349085]	1
GO:0050729	positive regulation of inflammatory response	biological process	IEA	6
GO:0001974	blood vessel remodeling	biological process	IEA	8
GO:0005525	GTP binding	molecular function	IEA	20
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	biological process	IEA	14
GO:0060445	branching involved in salivary gland morphogenesis	biological process	IEA	3
GO:0005829	cytosol	cellular component	IDA[24349085]	223
GO:0003810	protein-glutamine gamma-glutamyltransferase activity	molecular function	IMP[24349085]; ISS	1
GO:0051260	protein homooligomerization	biological process	IEA	13
GO:0043065	positive regulation of apoptotic process	biological process	IMP[24349085]	25
GO:0048661	positive regulation of smooth muscle cell proliferation	biological process	IEA	11
GO:0005739	mitochondrion	cellular component	IDA[24349085]	75
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway	biological process	IEA	6
GO:0031226	intrinsic component of plasma membrane	cellular component	IDA[2578891]; IMP[8105889]	3
GO:0018153	isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine	biological process	IEA	1
GO:0045785	positive regulation of cell adhesion	biological process	ISS	4
GO:0005515	protein binding	molecular function	IPI[16301118]	563
GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration	biological process	IMP[24349085]	1
GO:0046872	metal ion binding	molecular function	IEA	115
GO:0043277	apoptotic cell clearance	biological process	IDA[19628791]	3
GO:0005925	focal adhesion	cellular component	IDA[21423176]	32
GO:0060662	salivary gland cavitation	biological process	IEA	2
GO:0070062	extracellular vesicular exosome	cellular component	IDA[19056867]	176

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa05040	Huntington's disease	6

Gene related BioCarta pathways (count: 1)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
plcdPathway	Phospholipase C d1 in phospholipid associated cell signaling	2

Gene related interactors from protein-protein interactions data in HPRD (count: 27)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
TGM2	MAP3K12	NO	in vitro	10922377
TGM2	PLCD1	NO	in vitro;in vivo	10518533 , 9512491
TGM2	SERPINF2	NO	in vitro	10963790 , 10958788
TGM2	SMAD2	NO	yeast 2-hybrid	15231748
TGM2	RHOA	NO	in vivo	11350930
TGM2	EIF5A	NO	in vitro;in vivo	9442029
TGM2	TUBB	YES	in vitro;in vivo	9973324
TGM2	RB1	NO	in vitro	9315663
TGM2	KPNA4	NO	in vitro;in vivo;yeast 2-hybrid	10100610
TGM2	S100A7	NO	in vitro	11258932
TGM2	RELA	NO	in vivo	16951195
TGM2	PPHLN1	NO	in vitro	12853457
TGM2	ACTB	NO	in vitro;in vivo	9252372
TGM2	KPNA3	NO	in vivo;yeast 2-hybrid	10100610
TGM2	FN1	NO	in vitro	11829448 , 11686302
TGM2	TMSB4X	NO	in vivo	10611475
TGM2	SPARC	NO	in vitro	7730416
TGM2	ITGB3	NO	in vitro;in vivo	10684262
TGM2	LTBP1	NO	in vitro	9060478
TGM2	ALDOA	NO	in vitro	1353685
TGM2	SMAD3	NO	yeast 2-hybrid	15231748
TGM2	HIST1H2BG	NO	in vivo	9973324
TGM2	HTT	YES	in vivo	11442349
TGM2	GSTP1	NO	in vivo	9973324
TGM2	CASP3	NO	in vitro	10556977
TGM2	HIST2H2BE	NO	in vitro;in vivo	9973324
TGM2	ITGB1	NO	in vivo	10684262

Related other genetic factors

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs6023059	chr20:38109369 - 38109369(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant	1(1/0/0)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 20	chr20:0-64444167	4 (0/3/1)
20p11-q13	chr20:17900000-64444167	1 (1/0/0)
20q11	chr20:28100000-39000000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 2)

Reference	ID in SZGene	Result Category
18561261	719	Positive
20926141	719	Positive

Gene relationship with MDD

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Region: chr20:38127387..38166578 View in gBrowse