Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	AGTR1
Previous Symbol	AGTR1B
Symbol Alias	AT1, AT2R1, AGTR1A, AT2R1A, HAT1R, AG2S, AT2R1B, AT1B
Approved Name	angiotensin II receptor, type 1
Previous Name	angiotensin receptor 1B
Location	3q24
Position	chr3:148697784-148743008, 1
External Links	HGNC: 336 Entrez Gene: 185 Ensembl: ENSG00000144891 UCSC: uc003ewh.4
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Gratacos, M.,2009	SNP: rs275645	Nominal associations with bipolar disorder was observed.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 35)

GO terms by PBA (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005887	integral component of plasma membrane	cellular component	IC[1378723]	158
GO:0016021	integral component of membrane	cellular component	NAS[8135787]	219
GO:0005886	plasma membrane	cellular component	IDA[19023134]; TAS	360

GO terms by database search (count: 32)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0050729	positive regulation of inflammatory response	biological process	TAS[17159080]	6
GO:0005515	protein binding	molecular function	IPI[1378723]	563
GO:0032430	positive regulation of phospholipase A2 activity	biological process	IMP[17069818]	1
GO:0010873	positive regulation of cholesterol esterification	biological process	IMP[18971559]	3
GO:0004945	angiotensin type II receptor activity	molecular function	IDA[15611106]	1
GO:0007186	G-protein coupled receptor signaling pathway	biological process	IDA[1378723]	64
GO:0001558	regulation of cell growth	biological process	NAS[17159080]	7
GO:2000379	positive regulation of reactive oxygen species metabolic process	biological process	TAS[17159080]	4
GO:0007204	positive regulation of cytosolic calcium ion concentration	biological process	IDA[1567413]	21
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway	biological process	NAS[17159080]	11
GO:0019722	calcium-mediated signaling	biological process	IDA[1567413]	9
GO:0046982	protein heterodimerization activity	molecular function	IPI[10993080]	42
GO:0038166	angiotensin-activated signaling pathway	biological process	IDA[1567413]	1
GO:0001596	angiotensin type I receptor activity	molecular function	IDA[10993080]; IPI[1378723]	1
GO:0086097	phospholipase C-activating angiotensin-activated signaling pathway	biological process	IDA[1378723]	1
GO:0003081	regulation of systemic arterial blood pressure by renin-angiotensin	biological process	IC[1378723]	2
GO:0031711	bradykinin receptor binding	molecular function	IPI[10993080]	2
GO:0002018	renin-angiotensin regulation of aldosterone production	biological process	NAS[17159080]	2
GO:0042312	regulation of vasodilation	biological process	IC[1378723]	4
GO:0010744	positive regulation of macrophage derived foam cell differentiation	biological process	IC[18971559]	4
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway	biological process	IDA[1567413]	6
GO:0002034	regulation of blood vessel size by renin-angiotensin	biological process	IC[10993080]	2
GO:0050727	regulation of inflammatory response	biological process	IC[1378723]	4
GO:0001822	kidney development	biological process	IMP[16116425]	13
GO:0007266	Rho protein signal transduction	biological process	IDA[15611106]	4
GO:0019229	regulation of vasoconstriction	biological process	IC[1378723]; IDA[15117835]; NAS[17159080]	10
GO:0034374	low-density lipoprotein particle remodeling	biological process	NAS[17069818]	5
GO:0032270	positive regulation of cellular protein metabolic process	biological process	IMP[18971559]	4
GO:0035813	regulation of renal sodium excretion	biological process	NAS[17159080]	2
GO:0033864	positive regulation of NAD(P)H oxidase activity	biological process	TAS[17159080]	2
GO:0060326	cell chemotaxis	biological process	IDA[15635042]	4
GO:0042127	regulation of cell proliferation	biological process	NAS[17159080]	14

Gene related KEGG pathways (count: 3)

KEGG pathways by PBA (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04020	Calcium signaling pathway	53

KEGG pathways by database search (count: 2)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	92
hsa04614	Renin-angiotensin system	4

Gene related BioCarta pathways (count: 3)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 3)

ID	Name	No. of Genes in BDgene
cardiacegfPathway	Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy	5
ace2Pathway	Angiotensin-converting enzyme 2 regulates heart function	4
At1rPathway	Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling	4

Gene related interactors from protein-protein interactions data in HPRD (count: 13)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
AGTR1	ADRBK2	YES	in vivo	8662816
AGTR1	GPRASP1	NO	in vitro	15452121
AGTR1	GRK5	NO	in vivo	8662816
AGTR1	HRAS	NO	in vitro;in vivo	8753867
AGTR1	NOS3	YES	in vitro	10510297
AGTR1	JAK2	NO	in vivo	7746328
AGTR1	RAB5A	NO	in vivo;yeast 2-hybrid	11682489
AGTR1	THOP1	NO	in vitro;yeast 2-hybrid	15376229
AGTR1	AGTRAP	NO	in vitro	11733189
AGTR1	ADRBK1	NO	in vivo	8662816
AGTR1	DNAJC14	NO	in vitro	12446598
AGTR1	RAF1	NO	in vitro;in vivo	8753867
AGTR1	ARRB1	NO	in vivo	11579203

Related other genetic factors

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs275645	chr3:148746667 - 148746667(1)	downstream_gene_variant	1(1/0/0)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 3	chr3:0-198295559	2 (0/2/0)
3q22.1-q25.31	chr3:129500000-157300000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr3:148697784..148743008 View in gBrowse