Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	WWOX
Symbol Alias	FOR, WOX1, SDR41C1
Approved Name	WW domain containing oxidoreductase
Previous Name	WW domain-containing oxidoreductase
Name Alias	short chain dehydrogenase/reductase family 41C, member 1
Location	16q23.1-q23.2
Position	chr16:78099413-79212667, 1
External Links	HGNC: 12799 Entrez Gene: 51741 Ensembl: ENSG00000186153 UCSC: uc002ffk.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Noor A., 2014		Selected stringent CNV related to this gene is validated by qPCR from BD case data.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 27)

GO terms by PBA (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0048037	cofactor binding	molecular function	TAS[10786676]	3
GO:0005634	nucleus	cellular component	IDA	283
GO:0005886	plasma membrane	cellular component	IDA[19366691]	360

GO terms by database search (count: 24)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005902	microvillus	cellular component	IDA[19366691]	2
GO:0005739	mitochondrion	cellular component	ISS	75
GO:0016055	Wnt signaling pathway	biological process	IEA	12
GO:0016491	oxidoreductase activity	molecular function	NAS[10861292]; TAS[10786676]	2
GO:0008202	steroid metabolic process	biological process	TAS[10786676]	4
GO:0048705	skeletal system morphogenesis	biological process	ISS	3
GO:0071560	cellular response to transforming growth factor beta stimulus	biological process	IDA[19366691]	2
GO:0001649	osteoblast differentiation	biological process	IEA	9
GO:0005794	Golgi apparatus	cellular component	IDA	60
GO:0055114	oxidation-reduction process	biological process	TAS[10786676]	43
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	biological process	IEA	2
GO:0019899	enzyme binding	molecular function	IPI[19366691]	34
GO:0046983	protein dimerization activity	molecular function	TAS[10786676]	19
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	biological process	ISS	2
GO:0090575	RNA polymerase II transcription factor complex	cellular component	ISS[19366691]	1
GO:0030178	negative regulation of Wnt signaling pathway	biological process	IDA[19465938]	5
GO:0050662	coenzyme binding	molecular function	TAS[10786676]	3
GO:0005737	cytoplasm	cellular component	IDA; TAS[10786676]	322
GO:0005829	cytosol	cellular component	IDA[19366691]; TAS	223
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	ISS	91
GO:0097191	extrinsic apoptotic signaling pathway	biological process	IEA	5
GO:0001105	RNA polymerase II transcription coactivator activity	molecular function	ISS[19366691]	4
GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	biological process	IEA	2
GO:0005515	protein binding	molecular function	IPI[15064722]	563

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 7)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
WWOX	TP53	NO	in vivo;yeast 2-hybrid	11058590 , 15580310 , 12514174 , 14965474
WWOX	TP73	NO	in vitro;in vivo	15070730
WWOX	EZR	NO	in vitro;in vivo	16438931
WWOX	TNK2	YES	in vivo	16288044
WWOX	UBB	NO	in vivo	16288044
WWOX	SRC	NO	in vitro;in vivo	15070730
WWOX	MAPK8	NO	in vivo;yeast 2-hybrid	12514174

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 3)

ID	Location	Size	Band	Type
CNV_Zhang[2009]_273	chr16:77497019-77634452 (Affymetrix SNP 6.0 array reference genome)	137433		Singleton deletions
CNV_Abdul Noor[2014]_23	chr16:76767852-76781687 (NCBI Build 36/hg18)	14000	16q23.1	deletion
CNV_Zhang[2009]_277	chr16:77200307-77342789 (Affymetrix SNP 6.0 array reference genome)	142482		Singleton deletions

Gene related other variants (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 16	chr16:0-90338345	5 (1/3/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr16:78099413..79212667 View in gBrowse