Gene Report

Basic Info
Approved Symbol GNAL
Approved Name guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
Location 18p11.22-p11.21
Position chr18:11688956-11885685, 1
External Links HGNC: 4388
Entrez Gene: 2774
Ensembl: ENSG00000141404
UCSC: uc002kqc.3
No. of Studies 2 (Positive: 0; Negative: 2; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Yosifova, A.,2009 SNP: rs1786568, rs1786569, rs1895689, rs602201 No SNP of this gene had significant association with BD in our population. Negative Comment on Study
Zill, P.,2003 Other variant: GNAL_intron10_T/G, GNAL_intron3_A/G In conclusion, our findings that genetic variants in the GNAL gene do not play a causal role in the etiology of bipolar disorder. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 19)

GO terms by PBA (count: 3)

GO terms by database search (count: 16)

Gene related KEGG pathways (count: 2)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors
Gene related SNPs (count: 31)

Literature-origin SNPs (count: 8)

LD-proxies (count: 23)

Gene related CNVs (count: 0)

Gene related other variants (count: 2)

Gene related regions (count: 5)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 1)

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Region: chr18:11688956..11885685 View in gBrowse
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