Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	TFAM
Previous Symbol	TCF6, TCF6L2
Approved Name	transcription factor A, mitochondrial
Location	10q21
Position	chr10:58385022-58399221, 1
External Links	HGNC: 11741 Entrez Gene: 7019 Ensembl: ENSG00000108064 UCSC: uc001jkf.4
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Ament, S. A., 2015		P-value=0.0011, OR=14.9. No individual gene had a significant burden of segregating rare variants in BD pedigrees after correcting for multiple tests, although several genes had suggestive trends.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 25)

GO terms by PBA (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	IMP[22037171]	66
GO:0008301	DNA binding, bending	molecular function	IDA[22037171]	1
GO:0005634	nucleus	cellular component	IDA[21630459]	283

GO terms by database search (count: 22)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003682	chromatin binding	molecular function	IDA[18063578]	23
GO:0010467	gene expression	biological process	TAS	41
GO:0005739	mitochondrion	cellular component	IDA	75
GO:0045893	positive regulation of transcription, DNA-templated	biological process	IDA[20410300]	58
GO:0033108	mitochondrial respiratory chain complex assembly	biological process	IEA	1
GO:0044822	poly(A) RNA binding	molecular function	IDA[22658674]	44
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	molecular function	IDA[22037171]	23
GO:0006996	organelle organization	biological process	TAS	23
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IDA[20410300]	91
GO:0006356	regulation of transcription from RNA polymerase I promoter	biological process	TAS[8333869]	1
GO:0005515	protein binding	molecular function	IPI[12897151]	563
GO:0070363	mitochondrial light strand promoter sense binding	molecular function	IDA[19304746]	1
GO:0007005	mitochondrion organization	biological process	TAS	8
GO:0005759	mitochondrial matrix	cellular component	TAS	11
GO:0006391	transcription initiation from mitochondrial promoter	biological process	IDA[20410300]; TAS	1
GO:0031072	heat shock protein binding	molecular function	IEA	6
GO:0006338	chromatin remodeling	biological process	IBA	8
GO:0006261	DNA-dependent DNA replication	biological process	TAS[8333869]	3
GO:0005829	cytosol	cellular component	TAS	223
GO:0006390	transcription from mitochondrial promoter	biological process	IMP[22037171]; TAS	2
GO:0042645	mitochondrial nucleoid	cellular component	IDA[18063578]	2
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	molecular function	IC	18

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
TFAM	PNP	NO	in vitro	12068295
TFAM	TFB2M	NO	in vitro	12068295
TFAM	TFB1M	NO	in vitro;in vivo	12068295 , 12897151

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 6)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
10p11.21-q22.1	chr10:34200000-73100000	1 (1/0/0)
Chr 10	chr10:0-133797422	3 (0/2/1)
10q11.21-q22.1	chr10:41600000-73100000	1 (0/0/1)
10q11-q21	chr10:39800000-68800000	1 (0/1/0)
10q21	chr10:51100000-68800000	4 (0/3/1)
10q21.1-2	chr10:51100000-62800000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr10:58385022..58399221 View in gBrowse