Gene Report

Basic Info
Approved Symbol XBP1
Previous Symbol XBP2
Approved Name X-box binding protein 1
Location 22q12.1
Position chr22:28794555-28800597, -1
External Links HGNC: 12801
Entrez Gene: 7494
Ensembl: ENSG00000100219
UCSC: uc032qkw.1
No. of Studies 3 (Positive: 2; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 3)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Kakiuchi, C.,2003 Other variant: XBP1_-116C>G These results indicate that the -116C-->G polymorphism in XBP1 causes an impairment of its positive feedback system and increases the risk of bipolar disorder. Positive Comment on Study
Cheng, D., 2014 SNP: rs2269577 The XBP1-116C/G polymorphism is associated with an increased risk of bipolar disorder in Asian population. Positive Comment on Study
Hou, S. J., 2004 Other variant: XBP1_-116C>G No association was demonstrated between this polymorphism and family history in bipolar disorder patients. These negative findings suggest that the XBP1 C--116G polymorphism does not play a major role in the pathogenesis of bipolar disorders in Chinese populations. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 101)

GO terms by PBA (count: 4)

GO terms by database search (count: 97)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Related other genetic factors
Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Gene related regions (count: 1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 4)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 1)

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Region: chr22:28794555..28800597 View in gBrowse
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