Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

ADD to My Gene Set

Comment on Gene

View All Comments on Gene

Basic Info

Approved Symbol	PAWR
Symbol Alias	par-4, PAR4
Approved Name	PRKC, apoptosis, WT1, regulator
Name Alias	prostate apoptosis response-4
Location	12q21.2
Position	chr12:79574979-79691097, -1
External Links	HGNC: 8614 Entrez Gene: 5074 Ensembl: ENSG00000177425 UCSC: uc001syx.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Kishi, T., 2008 (a)	SNP: rs17005769, rs2400546, rs2463169, rs4842318, rs7305141 Haplotype: rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141(), rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141(GAGTA), rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141(GAACG), rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141(ATGCA), rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141(GAGCG), rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141(AAGCA)	Our results suggest that the PAWR does not play a major role in schizophrenia or mood disorders in the Japanese population.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 22)

GO terms by PBA (count: 4)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IDA[14627703]	283
GO:0003779	actin binding	molecular function	ISS	24
GO:0003714	transcription corepressor activity	molecular function	TAS[8943350]	21
GO:0005886	plasma membrane	cellular component	IDA	360

GO terms by database search (count: 18)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0043065	positive regulation of apoptotic process	biological process	NAS[11585763]	25
GO:0005515	protein binding	molecular function	IPI[11755531]	563
GO:0005737	cytoplasm	cellular component	IDA[14627703]	322
GO:0043522	leucine zipper domain binding	molecular function	IPI[14627703]	2
GO:0015629	actin cytoskeleton	cellular component	IDA	18
GO:0042094	interleukin-2 biosynthetic process	biological process	IEA	1
GO:0005884	actin filament	cellular component	ISS	9
GO:0008285	negative regulation of cell proliferation	biological process	TAS[8943350]	41
GO:0006915	apoptotic process	biological process	ISS	39
GO:0042986	positive regulation of amyloid precursor protein biosynthetic process	biological process	IEA	1
GO:0097190	apoptotic signaling pathway	biological process	IEA	13
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:0030889	negative regulation of B cell proliferation	biological process	IEA	5
GO:0042130	negative regulation of T cell proliferation	biological process	IEA	6
GO:0050860	negative regulation of T cell receptor signaling pathway	biological process	IEA	1
GO:0051017	actin filament bundle assembly	biological process	ISS	1
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	TAS[8943350]	62
GO:0019899	enzyme binding	molecular function	IDA[15671026]	34

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 11)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
PAWR	SLC5A7	NO	in vitro;in vivo	15090548
PAWR	AATF	NO	in vivo	14627703
PAWR	PRKCZ	YES	in vitro;in vivo	8797824
PAWR	THAP1	NO	yeast 2-hybrid	12717420
PAWR	PML	NO	in vitro;in vivo	12717420
PAWR	TFPT	NO	in vitro;in vivo;yeast 2-hybrid	16229834
PAWR	RRAS2	NO	yeast 2-hybrid	16169070
PAWR	HSPA5	YES	in vitro;in vivo	19632185
PAWR	ATP5C1	NO	yeast 2-hybrid	16169070
PAWR	DAPK3	NO	in vitro;in vivo	12917339 , 10602480
PAWR	WT1	NO	in vitro;in vivo;yeast 2-hybrid	8943350

Related other genetic factors

Gene related SNPs (count: 51)

Literature-origin SNPs (count: 5)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs2463169	chr12:79685268 - 79685268(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)
rs2400546	chr12:79670586 - 79670586(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs4842318	chr12:79650387 - 79650387(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs7305141	chr12:79621793 - 79621793(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs17005769	chr12:79661347 - 79661347(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)

LD-proxies (count: 46)

rs_ID	Location	Functional Annotation
rs2307220	chr12:79592094 - 79592094(1)	3_prime_UTR_variant; downstream_gene_variant; intron_variant; non_coding_transcript_variant
rs3789994	chr12:79592875 - 79592875(1)	intron_variant; non_coding_transcript_variant
rs7971769	chr12:79570412 - 79570412(1)	downstream_gene_variant
rs7968442	chr12:79631291 - 79631291(1)	intron_variant; non_coding_transcript_variant
rs8176857	chr12:79623496 - 79623496(1)	intron_variant; non_coding_transcript_variant
rs7294911	chr12:79629330 - 79629330(1)	intron_variant; non_coding_transcript_variant
rs10778683	chr12:79630240 - 79630240(1)	intron_variant; non_coding_transcript_variant
rs9651966	chr12:79634958 - 79634958(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs10778681	chr12:79617884 - 79617884(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant
rs8176875	chr12:79620408 - 79620408(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant
rs7305134	chr12:79621779 - 79621779(1)	intron_variant; non_coding_transcript_variant
rs7306065	chr12:79621813 - 79621813(1)	intron_variant; non_coding_transcript_variant
rs7953683	chr12:79599924 - 79599924(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs6539469	chr12:79603314 - 79603314(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant
rs7979987	chr12:79604857 - 79604857(1)	intron_variant; non_coding_transcript_variant
rs7955388	chr12:79612913 - 79612913(1)	intron_variant; non_coding_transcript_variant
rs11503488	chr12:79575731 - 79575731(1)	intron_variant; non_coding_transcript_variant
rs11114185	chr12:79576559 - 79576559(1)	intron_variant; non_coding_transcript_variant
rs8176914	chr12:79590919 - 79590919(1)	3_prime_UTR_variant; downstream_gene_variant; intron_variant; non_coding_transcript_variant
rs1553526	chr12:79584560 - 79584560(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant
rs4842316	chr12:79580785 - 79580785(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant
rs12827748	chr12:79694798 - 79694798(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs2808356	chr12:79666818 - 79666818(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant
rs1880884	chr12:79662191 - 79662191(1)	intron_variant; non_coding_transcript_variant
rs1880883	chr12:79661986 - 79661986(1)	intron_variant; non_coding_transcript_variant
rs7134813	chr12:79661452 - 79661452(1)	intron_variant; non_coding_transcript_variant
rs10778686	chr12:79678175 - 79678175(1)	intron_variant; non_coding_transcript_variant
rs10778685	chr12:79672400 - 79672400(1)	intron_variant; non_coding_transcript_variant
rs2177973	chr12:79670877 - 79670877(1)	intron_variant; non_coding_transcript_variant
rs7300145	chr12:79668376 - 79668376(1)	intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant
rs11114201	chr12:79645399 - 79645399(1)	intron_variant; non_coding_transcript_variant
rs2463168	chr12:79643021 - 79643021(1)	intron_variant; non_coding_transcript_variant
rs4441080	chr12:79636927 - 79636927(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs2049589	chr12:79635736 - 79635736(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs10862007	chr12:79656185 - 79656185(1)	intron_variant; non_coding_transcript_variant
rs3842842	chr12:79655109 - 79655109(1)	intron_variant; non_coding_transcript_variant
rs2491341	chr12:79651713 - 79651713(1)	intron_variant; non_coding_transcript_variant
rs2049590	chr12:79649380 - 79649380(1)	intron_variant; non_coding_transcript_variant
rs11114178	chr12:79570394 - 79570394(1)	downstream_gene_variant
rs11114183	chr12:79573943 - 79573943(1)	downstream_gene_variant
rs2430866	chr12:79686838 - 79686838(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs8176805	chr12:79690012 - 79690012(1)	downstream_gene_variant; missense_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant
rs7307647	chr12:79682638 - 79682638(1)	intron_variant; non_coding_transcript_variant
rs2463108	chr12:79684644 - 79684644(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant
rs2694831	chr12:79693000 - 79693000(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs6539471	chr12:79695615 - 79695615(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 12	chr12:0-133275309	3 (0/3/0)
12q	chr12:38200000-133851895	1 (1/0/0)
12q21	chr12:71100000-92200000	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 2)

Reference	ID in SZGene	Result Category
18281137	656	Positive
18085546	656	Negative

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Description	Category in MDD
18085546	Our results suggest that the PAWR does not play a major role in mood disorders in the Japanese population.	Negative

Overlap with MDD from candidate gene intersection analysis (count: 2)

Reference	Description	Category in MDD	Link in MK4MDD
20735158	Rs7305141-rs2307223-rs8176874 were significantly associated with MDD after correction for multiple testing (corrected P < 0.05).	Pos	PAWR

View in gBrowse

Region: chr12:79574979..79691097 View in gBrowse