Gene Report

Basic Info
Approved Symbol PAWR
Symbol Alias par-4, PAR4
Approved Name PRKC, apoptosis, WT1, regulator
Name Alias prostate apoptosis response-4
Location 12q21.2
Position chr12:79574979-79691097, -1
External Links HGNC: 8614
Entrez Gene: 5074
Ensembl: ENSG00000177425
UCSC: uc001syx.3
No. of Studies 1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Kishi, T., 2008 (a) SNP: rs17005769, rs2400546, rs2463169, rs4842318, rs7305141
Haplotype: rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141(), rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141(GAGTA), rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141(GAACG), rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141(ATGCA), rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141(GAGCG), rs2463169 - rs2400546 - rs17005769 - rs4842318 - rs7305141(AAGCA)
Our results suggest that the PAWR does not play a major role in schizophrenia or mood disorders in the Japanese population. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 22)

GO terms by PBA (count: 4)

GO terms by database search (count: 18)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 11)

Related other genetic factors
Gene related SNPs (count: 51)

Literature-origin SNPs (count: 5)

LD-proxies (count: 46)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 2)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 2)

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Region: chr12:79574979..79691097 View in gBrowse
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