Gene Report

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Basic Info

Approved Symbol	GPC5
Approved Name	glypican 5
Name Alias	glypican proteoglycan 5
Location	13q32
Position	chr13:91398607-92873682, 1
External Links	HGNC: 4453 Entrez Gene: 2262 Ensembl: ENSG00000179399 UCSC: uc010tif.2
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
McQuillin, A.,2011		Gene related CNV occurred in two or more cases but not in controls.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 18)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0005887	integral component of plasma membrane	cellular component	TAS[7657705]	158

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005796	Golgi lumen	cellular component	TAS	9
GO:0005615	extracellular space	cellular component	IEA	85
GO:0044281	small molecule metabolic process	biological process	TAS	117
GO:0001523	retinoid metabolic process	biological process	TAS	5
GO:0007603	phototransduction, visible light	biological process	TAS	6
GO:0043202	lysosomal lumen	cellular component	TAS	4
GO:0005975	carbohydrate metabolic process	biological process	TAS	12
GO:0030203	glycosaminoglycan metabolic process	biological process	TAS	5
GO:0031225	anchored component of membrane	cellular component	IEA	11
GO:0005576	extracellular region	cellular component	TAS	97
GO:0006024	glycosaminoglycan biosynthetic process	biological process	TAS	3
GO:0005578	proteinaceous extracellular matrix	cellular component	IEA	19
GO:0043395	heparan sulfate proteoglycan binding	molecular function	IEA	3
GO:0009405	pathogenesis	biological process	TAS	13
GO:0030204	chondroitin sulfate metabolic process	biological process	TAS	2
GO:0006027	glycosaminoglycan catabolic process	biological process	TAS	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_McQuillin[2011]_19	chr13:90848887-92317488 (NCBI Build 36 (hg18))	1468602

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
13q21-33	chr13:54700000-109600000	1 (0/0/1)
13q22-32	chr13:72800000-101100000	1 (0/0/1)
13q31-q34	chr13:78500000-114364328	1 (0/0/1)
Chr 13	chr13:0-114364328	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr13:91398607..92873682 View in gBrowse