Gene Report

Basic Info
Approved Symbol NR2E1
Previous Symbol TLX
Symbol Alias TLL, XTLL
Approved Name nuclear receptor subfamily 2, group E, member 1
Location 6q21
Position chr6:108166058-108188809, 1
External Links HGNC: 7973
Entrez Gene: 7101
Ensembl: ENSG00000112333
UCSC: uc032xhm.1
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Kumar, R. A., 2008 SNP: rs127503, rs217520, rs2233488, rs588409
Other variant: NR2E1_g. -1429
NR2E1was associated with bipolar disorder I and II [odds ratio (OR=0.77, P=0.013), bipolar disorder I (OR=0.77, P=0.015), bipolar disorder in females (OR=0.72, P=0.009), and with age at onset 25 years (OR=0.67, P=0.006)], all of which remained significant after correcting for multiple comparisons.. NR2E1was associated with bipolar disorder. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 40)

GO terms by PBA (count: 3)

GO terms by database search (count: 37)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors
Gene related SNPs (count: 9)

Literature-origin SNPs (count: 4)

LD-proxies (count: 5)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Gene related regions (count: 5)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

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Region: chr6:108166058..108188809 View in gBrowse
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