Gene Report

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Basic Info

Approved Symbol	RASGRF2
Symbol Alias	GRF2, Ras-GRF2
Approved Name	Ras protein-specific guanine nucleotide-releasing factor 2
Location	5q13
Position	chr5:80960672-81230156, 1
External Links	HGNC: 9876 Entrez Gene: 5924 Ensembl: ENSG00000113319 UCSC: uc003kha.2
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Jamain, S., 2014	SNP: rs34116	It showed nominal evidence for association with BD.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007268	synaptic transmission	biological process	TAS	116
GO:0005089	Rho guanyl-nucleotide exchange factor activity	molecular function	IEA	7
GO:0005516	calmodulin binding	molecular function	IEA	20
GO:0005886	plasma membrane	cellular component	TAS	360

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity	biological process	IEA	6
GO:0051056	regulation of small GTPase mediated signal transduction	biological process	TAS	9
GO:0043065	positive regulation of apoptotic process	biological process	TAS	25
GO:0007264	small GTPase mediated signal transduction	biological process	TAS	18
GO:0005789	endoplasmic reticulum membrane	cellular component	IEA	52
GO:0043547	positive regulation of GTPase activity	biological process	IEA	30
GO:0048011	neurotrophin TRK receptor signaling pathway	biological process	TAS	33
GO:0005829	cytosol	cellular component	TAS	223
GO:0097190	apoptotic signaling pathway	biological process	TAS	13

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04010	MAPK signaling pathway	39

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs34116	chr5:81146180 - 81146180(1)	intron_variant; NMD_transcript_variant	1(0/0/1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 5	chr5:0-181538259	3 (0/2/1)
5q14	chr5:77600000-93000000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr5:80960672..81230156 View in gBrowse