Gene Report

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Basic Info

Approved Symbol	ITGB8
Approved Name	integrin, beta 8
Location	7p15.3
Position	chr7:20330702-20415754, 1
External Links	HGNC: 6163 Entrez Gene: 3696 Ensembl: ENSG00000105855 UCSC: uc003suu.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Chen, X., 2015		ITGB8 has been implicated in SCZ, and Alzheimer disease.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007155	cell adhesion	biological process	TAS[1918072]	42
GO:0004872	receptor activity	molecular function	IEA	19
GO:0005102	receptor binding	molecular function	IEA	37
GO:0005886	plasma membrane	cellular component	TAS	360

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:1990430	extracellular matrix protein binding	molecular function	IDA[7525578]	1
GO:0007229	integrin-mediated signaling pathway	biological process	IEA	4
GO:0009986	cell surface	cellular component	IDA[1918072]	40
GO:0007160	cell-matrix adhesion	biological process	IMP[7525578]	11
GO:0034686	integrin alphav-beta8 complex	cellular component	IDA[1918072]	1
GO:0010629	negative regulation of gene expression	biological process	IMP[24312400]	12
GO:0030198	extracellular matrix organization	biological process	TAS	26
GO:0070062	extracellular vesicular exosome	cellular component	IDA[19056867]	176
GO:0010628	positive regulation of gene expression	biological process	IMP[24312400]	23
GO:0001573	ganglioside metabolic process	biological process	IEA	1
GO:0060674	placenta blood vessel development	biological process	TAS[19267251]	1
GO:0051216	cartilage development	biological process	IMP[24312400]	6
GO:0008305	integrin complex	cellular component	TAS[1918072]	3

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in BDgene
hsa04514	Cell adhesion molecules (CAMs)	14
hsa04510	Focal adhesion	22
hsa04512	ECM-receptor interaction	9

ID	Name	No. of Genes in BDgene	Brief Description
hsa04810	Regulation of actin cytoskeleton	24

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
ITGB8	VTN	NO	in vitro	11156415
ITGB8	ITGAV	NO	in vivo	1918072
ITGB8	TGFB1	NO	in vitro;in vivo	11970960

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
7p22.2-p21.1	chr7:2800000-20900000	1 (0/0/1)
Chr 7	chr7:0-159345973	3 (0/3/0)
7p21.1	chr7:16500000-20900000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr7:20330702..20415754 View in gBrowse