Gene Report

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Basic Info

Approved Symbol	TIAM2
Symbol Alias	STEF
Approved Name	T-cell lymphoma invasion and metastasis 2
Location	6q25
Position	chr6:154832697-155257723, 1
External Links	HGNC: 11806 Entrez Gene: 26230 Ensembl: ENSG00000146426 UCSC: uc003qqe.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Hattori, E.,2009	SNP: rs4869843	After the two-stage analysis, markers in this gene remained nominally significant (allelic P<0.05) with the same allele being consistently over-represented in both the first and the follow-up stages.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 18)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005089	Rho guanyl-nucleotide exchange factor activity	molecular function	IEA	7
GO:0005085	guanyl-nucleotide exchange factor activity	molecular function	TAS[10512681]	3
GO:0016020	membrane	cellular component	IEA	137

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0048011	neurotrophin TRK receptor signaling pathway	biological process	TAS	33
GO:0030175	filopodium	cellular component	IEA	5
GO:0044255	cellular lipid metabolic process	biological process	TAS	13
GO:0070062	extracellular vesicular exosome	cellular component	IDA[19056867]	176
GO:0005829	cytosol	cellular component	TAS	223
GO:0097190	apoptotic signaling pathway	biological process	TAS	13
GO:0030426	growth cone	cellular component	IEA	22
GO:0007264	small GTPase mediated signal transduction	biological process	TAS	18
GO:0044281	small molecule metabolic process	biological process	TAS	117
GO:0005057	receptor signaling protein activity	molecular function	IEA	7
GO:0005096	GTPase activator activity	molecular function	IEA	19
GO:0043547	positive regulation of GTPase activity	biological process	IEA	30
GO:0043065	positive regulation of apoptotic process	biological process	TAS	25
GO:0051056	regulation of small GTPase mediated signal transduction	biological process	TAS	9
GO:0030027	lamellipodium	cellular component	IEA	9

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04810	Regulation of actin cytoskeleton	24

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
TIAM2	PARD3	NO	in vitro;in vivo	15723051

Related other genetic factors

Gene related SNPs (count: 8)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs4869843	chr6:155086849 - 155086849(1)	intron_variant; non_coding_transcript_variant; upstream_gene_variant	1(1/0/0)

rs_ID	Location	Functional Annotation
rs17085907	chr6:155063306 - 155063306(1)	intron_variant; non_coding_transcript_variant
rs4870347	chr6:155073909 - 155073909(1)	intron_variant; non_coding_transcript_variant
rs10223883	chr6:155099557 - 155099557(1)	intron_variant
rs6915661	chr6:155090472 - 155090472(1)	downstream_gene_variant; intron_variant
rs13202771	chr6:155095394 - 155095394(1)	intron_variant
rs12661761	chr6:155084270 - 155084270(1)	intron_variant; non_coding_transcript_variant
rs17798743	chr6:155084929 - 155084929(1)	intron_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 6	chr6:0-170805979	3 (0/3/0)
6q25	chr6:148500000-160600000	2 (0/1/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr6:154832697..155257723 View in gBrowse