BDgene

Gene Report

Basic Info
Approved Symbol GNB3
Approved Name guanine nucleotide binding protein (G protein), beta polypeptide 3
Location 12p13
Position chr12:6839954-6847393, 1
External Links HGNC: 4400
Entrez Gene: 2784
Ensembl: ENSG00000111664
UCSC: uc001qrd.3
No. of Studies 2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Yosifova, A.,2009 SNP: rs5443 Significant association of SNP in this gene with BD in our population was observed. Positive Comment on Study
Kunugi, H.,2002 Other variant: GNB3_C825T We obtained no evidence for an association of the polymorphism with any diagnostic group. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 15)

GO terms by PBA (count: 3)

GO terms by database search (count: 12)


Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)


Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 6)

Related other genetic factors
Gene related SNPs (count: 4)

Literature-origin SNPs (count: 1)

LD-proxies (count: 3)


Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 3)


Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 1)


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Region: chr12:6839954..6847393 View in gBrowse
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