Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	INO80
Previous Symbol	INOC1
Symbol Alias	KIAA1259, Ino80, hINO80, INO80A
Approved Name	INO80 complex subunit
Previous Name	INO80 complex homolog 1 (S. cerevisiae), "INO80 homolog (S. cerevisiae)"
Name Alias	INO80 complex subunit A
Location	15q15.1
Position	chr15:40978880-41116354, -1
External Links	HGNC: 26956 Entrez Gene: 54617 Ensembl: ENSG00000128908 UCSC: uc001zni.4
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014	SNP: rs496499	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 24)

GO terms by PBA (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003677	DNA binding	molecular function	IDA[16298340]	83
GO:0005634	nucleus	cellular component	IDA	283
GO:0003779	actin binding	molecular function	IEA	24

GO terms by database search (count: 21)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0031011	Ino80 complex	cellular component	IDA[18026119]	3
GO:0043014	alpha-tubulin binding	molecular function	IMP[20237820]	4
GO:0010571	positive regulation of nuclear cell cycle DNA replication	biological process	IMP[20237820]	1
GO:0000724	double-strand break repair via homologous recombination	biological process	IMP[18026119]	9
GO:0051225	spindle assembly	biological process	IMP[20237820]	3
GO:0030307	positive regulation of cell growth	biological process	IMP[20237820]	8
GO:0006302	double-strand break repair	biological process	IMP[20687897]	6
GO:0005874	microtubule	cellular component	IEA	24
GO:0070914	UV-damage excision repair	biological process	IMP[20855601]	2
GO:0051301	cell division	biological process	IEA	20
GO:0003678	DNA helicase activity	molecular function	IDA[16298340]	2
GO:0034644	cellular response to UV	biological process	IMP[18026119]	5
GO:2000045	regulation of G1/S transition of mitotic cell cycle	biological process	IMP[20237820]	1
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IMP[20687897]	91
GO:0005515	protein binding	molecular function	IPI[18026119]	563
GO:0006338	chromatin remodeling	biological process	IDA[16298340]	8
GO:0005524	ATP binding	molecular function	IEA	118
GO:0032508	DNA duplex unwinding	biological process	IDA[16298340]	5
GO:0071479	cellular response to ionizing radiation	biological process	IMP[20687897]	3
GO:0016887	ATPase activity	molecular function	IDA[16298340]	13
GO:0000070	mitotic sister chromatid segregation	biological process	IMP[20237820]	3

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 22)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs496499	chr15:41106118 - 41106118(1)	intron_variant; NMD_transcript_variant; upstream_gene_variant	1(0/1/0)

LD-proxies (count: 21)

rs_ID	Location	Functional Annotation
rs7167166	chr15:41064211 - 41064211(1)	intron_variant; NMD_transcript_variant
rs2412600	chr15:41055869 - 41055869(1)	intron_variant; NMD_transcript_variant
rs2412599	chr15:41055773 - 41055773(1)	intron_variant; NMD_transcript_variant
rs7173146	chr15:41040949 - 41040949(1)	intron_variant; NMD_transcript_variant
rs691069	chr15:41082776 - 41082776(1)	intron_variant; NMD_transcript_variant
rs16971463	chr15:41078428 - 41078428(1)	intron_variant; NMD_transcript_variant
rs7172555	chr15:41070762 - 41070762(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs2947496	chr15:41069027 - 41069027(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant
rs11070319	chr15:41007883 - 41007883(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; upstream_gene_variant
rs4924533	chr15:40997981 - 40997981(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs16971413	chr15:40996080 - 40996080(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs8043232	chr15:40990173 - 40990173(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs4468583	chr15:41036455 - 41036455(1)	intron_variant; NMD_transcript_variant
rs9806344	chr15:41034513 - 41034513(1)	intron_variant; NMD_transcript_variant
rs3101438	chr15:41021929 - 41021929(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs7174513	chr15:41019743 - 41019743(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs16971263	chr15:40985976 - 40985976(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant
rs474351	chr15:41096773 - 41096773(1)	intron_variant; NMD_transcript_variant
rs690773	chr15:41105138 - 41105138(1)	intron_variant; NMD_transcript_variant; upstream_gene_variant
rs518137	chr15:41089315 - 41089315(1)	intron_variant; NMD_transcript_variant
rs2928147	chr15:41092451 - 41092451(1)	intron_variant; NMD_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
15q15.1-21.2	chr15:39800000-52600000	1 (0/0/1)
Chr 15	chr15:0-101991189	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr15:40978880..41116354 View in gBrowse