Gene Report

Basic Info
Approved Symbol CSMD1
Symbol Alias KIAA1890, PPP1R24
Approved Name CUB and Sushi multiple domains 1
Name Alias protein phosphatase 1, regulatory subunit 24
Location 8p23.2
Position chr8:2935353-4994972, -1
External Links HGNC: 14026
Entrez Gene: 64478
Ensembl: ENSG00000183117
UCSC: uc022aqr.1
No. of Studies 4 (Positive: 2; Negative: 1; trend: 1)
Overlap with SZ? NO
Overlap with MDD? NO
Gene related studies (count: 4)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Xu, W., 2014 SNP: rs10089209, rs1154037, rs12056919, rs17063147, rs922790 These include SNP rs1154037 in CSMD1, for which the intronic SNP rs4875310 was suggestive significant in the Sklar et al. 2008 study (p = 3.74×10-5). Negative Comment on Study
Hattori, E.,2009 SNP: rs10503227 After the two-stage analysis, markers in this gene remained nominally significant (allelic P<0.05) with the same allele being consistently over-represented in both the first and the follow-up stages. Positive Comment on Study
Johnson, C.,2009 Monte-Carlo Simulation P-value = 0.0011. One of Genes That Harbor Overlapping Clusters of 4 Nominally Positive SNPs Whose Allele Frequencies Distinguish Individuals With Bipolar Disorder From Controls With P<0.05 Nominal Significance From at Least Three of the Four Samples in This Analysis Positive Comment on Study
Jamain, S., 2014 SNP: rs1504772 It showed nominal evidence for association with BD. Trend Comment on Study
Gene functional annotation
Gene related GO terms (count: 1)

GO terms by PBA (count: 1)

GO terms by database search (count: 0)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors
Gene related SNPs (count: 49)

Literature-origin SNPs (count: 8)

LD-proxies (count: 41)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

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Region: chr8:2935353..4994972 View in gBrowse
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