Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	VIPR2
Symbol Alias	VPAC2, VPAC2R
Approved Name	vasoactive intestinal peptide receptor 2
Name Alias	VIP and PACAP receptor 2
Location	7q36.3
Position	chr7:159028175-159144957, -1
External Links	HGNC: 12695 Entrez Gene: 7434 Ensembl: ENSG00000106018 UCSC: uc003woh.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Soria, V.,2010	SNP: rs12670064, rs2540352, rs3793227, rs885861	Significant associations of VIPR2 gene were found in BPD patients.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 9)

GO terms by PBA (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0005887	integral component of plasma membrane	cellular component	TAS[7811244]	158

GO terms by database search (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007190	activation of adenylate cyclase activity	biological process	IEA	12
GO:0004999	vasoactive intestinal polypeptide receptor activity	molecular function	IEA	1
GO:0004930	G-protein coupled receptor activity	molecular function	TAS[7811244]	26
GO:0007267	cell-cell signaling	biological process	TAS[8757618]	29
GO:0007165	signal transduction	biological process	TAS[7811244]	136
GO:0007186	G-protein coupled receptor signaling pathway	biological process	IEA	64
GO:0048662	negative regulation of smooth muscle cell proliferation	biological process	IEA	7

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	92

Gene related BioCarta pathways (count: 1)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
vipPathway	Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells	9

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 39)

Literature-origin SNPs (count: 4)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs885861	chr7:159028856 - 159028856(1)	3_prime_UTR_variant; downstream_gene_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant	1(1/0/0)
rs3793227	chr7:159093237 - 159093237(1)	intron_variant	1(1/0/0)
rs12670064	chr7:159076724 - 159076724(1)	intron_variant	1(1/0/0)
rs2540352	chr7:159071067 - 159071067(1)	intron_variant	1(0/1/0)

LD-proxies (count: 35)

rs_ID	Location	Functional Annotation
rs885863	chr7:159028278 - 159028278(1)	3_prime_UTR_variant; downstream_gene_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant
rs1062610	chr7:159028484 - 159028484(1)	3_prime_UTR_variant; downstream_gene_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant
rs3793241	chr7:159126751 - 159126751(1)	intron_variant
rs3793223	chr7:159070883 - 159070883(1)	intron_variant
rs2270313	chr7:159103826 - 159103826(1)	missense_variant; synonymous_variant
rs2270314	chr7:159103933 - 159103933(1)	intron_variant
rs3793228	chr7:159098815 - 159098815(1)	intron_variant; upstream_gene_variant
rs3828962	chr7:159107915 - 159107915(1)	intron_variant
rs7797488	chr7:159092164 - 159092164(1)	intron_variant
rs17837875	chr7:159110392 - 159110392(1)	intron_variant
rs10263510	chr7:159085274 - 159085274(1)	intron_variant
rs3793230	chr7:159108248 - 159108248(1)	intron_variant
rs3793229	chr7:159108040 - 159108040(1)	intron_variant
rs2864943	chr7:159107120 - 159107120(1)	intron_variant
rs3793222	chr7:159070845 - 159070845(1)	intron_variant
rs2864944	chr7:159105595 - 159105595(1)	intron_variant
rs17837879	chr7:159114973 - 159114973(1)	downstream_gene_variant; intron_variant
rs3750072	chr7:159110050 - 159110050(1)	intron_variant
rs3793232	chr7:159109734 - 159109734(1)	intron_variant
rs6459922	chr7:159109202 - 159109202(1)	intron_variant
rs3793239	chr7:159125308 - 159125308(1)	intron_variant
rs6459927	chr7:159124557 - 159124557(1)	intron_variant
rs6459925	chr7:159121518 - 159121518(1)	intron_variant
rs6973238	chr7:159115605 - 159115605(1)	downstream_gene_variant; intron_variant
rs2540357	chr7:159049684 - 159049684(1)	intron_variant
rs3812313	chr7:159139768 - 159139768(1)	intron_variant
rs2467807	chr7:159057191 - 159057191(1)	intron_variant
rs17837880	chr7:159122104 - 159122104(1)	intron_variant
rs3812304	chr7:159079053 - 159079053(1)	intron_variant
rs3793237	chr7:159119342 - 159119342(1)	intron_variant
rs12668638	chr7:159079121 - 159079121(1)	intron_variant
rs6459928	chr7:159135878 - 159135878(1)	intron_variant
rs3815516	chr7:159069486 - 159069486(1)	intron_variant
rs17837881	chr7:159122391 - 159122391(1)	intron_variant
rs7789969	chr7:159072516 - 159072516(1)	intron_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
7q36.3	chr7:155200000-159345973	1 (0/0/1)
Chr 7	chr7:0-159345973	3 (0/3/0)
7q34-qter	chr7:138500000-159345973	1 (0/1/0)
7q36	chr7:148200000-159345973	3 (0/0/3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Reference	ID in SZGene	Result Category
17387318	487	Negative

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Description	Category in MDD
20072116	Significant associations of VIPR2 gene were found in MDD patients.	Positive

Overlap with MDD from candidate gene intersection analysis (count: 0)

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Region: chr7:159028175..159144957 View in gBrowse