Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	ADRB2
Previous Symbol	ADRB2R
Symbol Alias	ADRBR, BAR, B2AR
Approved Name	adrenoceptor beta 2, surface
Previous Name	adrenergic, beta-2-, receptor, surface
Location	5q31-q32
Position	chr5:148825245-148828687, 1
External Links	HGNC: 286 Entrez Gene: 154 Ensembl: ENSG00000169252 UCSC: uc003lpr.2
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Dizier, M. H.,2012		Gene-based approach:Empirical P-value = 0.003(EAAO versus HC); Empirical P-value = 0.81(LAAO versus HC); ADRB2 (beta-2adrenoreceptor) gene region that is specifically associated with the early onset form of BD.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 37)

GO terms by PBA (count: 5)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005764	lysosome	cellular component	TAS[9507004]	16
GO:0005887	integral component of plasma membrane	cellular component	IDA[12297500]	158
GO:0005886	plasma membrane	cellular component	IDA[9235896]; TAS	360
GO:0005634	nucleus	cellular component	IEA	283
GO:0043235	receptor complex	cellular component	IDA[15123695]	20

GO terms by database search (count: 32)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0030501	positive regulation of bone mineralization	biological process	IEA	4
GO:0002024	diet induced thermogenesis	biological process	IEA	1
GO:0015459	potassium channel regulator activity	molecular function	IDA[12297500]	11
GO:0009409	response to cold	biological process	IEA	7
GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure	biological process	IEA	1
GO:0005768	endosome	cellular component	TAS[10734107]	27
GO:1903146	regulation of mitochondrion degradation	biological process	IMP[22020285]	5
GO:0051380	norepinephrine binding	molecular function	IDA[15123695]	2
GO:0042803	protein homodimerization activity	molecular function	IDA[15123695]	71
GO:0002028	regulation of sodium ion transport	biological process	IEA	9
GO:0050873	brown fat cell differentiation	biological process	IEA	1
GO:0005515	protein binding	molecular function	IPI[15123695]	563
GO:0045453	bone resorption	biological process	IEA	3
GO:0071875	adrenergic receptor signaling pathway	biological process	IDA[15123695]; IEA	4
GO:0008179	adenylate cyclase binding	molecular function	IEA	2
GO:0042312	regulation of vasodilation	biological process	IEA	4
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IEA	91
GO:0045986	negative regulation of smooth muscle contraction	biological process	IEA	1
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway	biological process	IEA	11
GO:0031649	heat generation	biological process	IEA	1
GO:0007166	cell surface receptor signaling pathway	biological process	TAS[1371121]	23
GO:0043410	positive regulation of MAPK cascade	biological process	IDA[15123695]	13
GO:0040015	negative regulation of multicellular organism growth	biological process	IEA	2
GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin	biological process	IDA[15123695]	2
GO:0008333	endosome to lysosome transport	biological process	TAS[9507004]	4
GO:0007190	activation of adenylate cyclase activity	biological process	IDA[15123695]	12
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	biological process	TAS[2823249]	10
GO:0016324	apical plasma membrane	cellular component	IEA	24
GO:0006898	receptor-mediated endocytosis	biological process	IDA[15123695]	12
GO:0031398	positive regulation of protein ubiquitination	biological process	IMP[19372219]	5
GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity	biological process	TAS[10734107]	5
GO:0004941	beta2-adrenergic receptor activity	molecular function	IDA[15123695]	1

Gene related KEGG pathways (count: 2)

KEGG pathways by PBA (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04020	Calcium signaling pathway	53

KEGG pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	92

Gene related BioCarta pathways (count: 2)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 2)

ID	Name	No. of Genes in BDgene	Brief Description
gcrPathway	Corticosteroids and cardioprotection	9
plcePathway	Phospholipase C-epsilon pathway	4

Gene related interactors from protein-protein interactions data in HPRD (count: 23)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
ADRB2	NEDD4	NO	in vivo	18544533
ADRB2	PRKCD	NO	in vivo	1848190
ADRB2	ARRB1	NO	in vivo	16407241
ADRB2	SLC9A3R2	NO	in vitro	9671706
ADRB2	GNA15	NO	in vivo	7608160 , 7797501
ADRB2	ADRB3	NO	in vivo	15123695
ADRB2	SRC	NO	in vitro	11013230 , 17170700
ADRB2	KCNJ6	NO	in vitro	12297500
ADRB2	GNA14	NO	in vivo	7797501
ADRB2	SLC9A3R1	NO	in vitro;in vivo	9560162 , 9671706
ADRB2	GRB2	NO	in vitro;in vivo	9830057
ADRB2	GRK5	NO	in vitro	8662852
ADRB2	AKAP12	NO	in vitro;in vivo	9880537 , 11309381
ADRB2	OPRD1	NO	in vivo	11278447
ADRB2	GRK6	NO	in vitro	9819198
ADRB2	GNA11	NO	in vivo	7797501
ADRB2	CSK	NO	in vitro	11278940
ADRB2	GPRASP1	NO	in vitro	15452121
ADRB2	ARR3	NO	in vitro;in vivo	11877451
ADRB2	AKAP5	YES	in vitro;in vivo	10753752
ADRB2	EIF2B1	NO	in vivo	9235896
ADRB2	INSR	NO	in vivo	8557631
ADRB2	KCNJ9	NO	in vitro;in vivo	12297500

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 5	chr5:0-181538259	3 (0/2/1)
5q31-q33	chr5:131200000-160500000	1 (1/0/0)
5q32	chr5:145100000-150400000	2 (0/2/0)
5q32-5q33.3	chr5:145100000-160500000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr5:148825245..148828687 View in gBrowse