Gene Report

ADD to My Gene Set

Basic Info

Approved Symbol	SLC15A1
Symbol Alias	PEPT1, HPECT1, HPEPT1
Approved Name	solute carrier family 15 (oligopeptide transporter), member 1
Name Alias	peptide transporter HPEPT1, "bA551M18.1.1 (solute carrier family 15 (oligopeptide transporter) member 1)", "solute carrier family 15 oligopeptide transporter member 1"
Location	13q32.3
Position	chr13:98683801-98752654, -1
External Links	HGNC: 10920 Entrez Gene: 6564 Ensembl: ENSG00000088386 UCSC: uc001vno.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Fallin, M. D.,2005		7 SNP typed, Median D'=0.72, Median r<sup>2</sup> =0.03, 3 LD blocks, 0.28 block coverage, there exists SNP or haplotype nominal P-value > 0.01 and <0.05 in SZ/SZA and all SNP or haplotype P-value > 0.05 in BP.. This gene is suggestive to SZ/SZA , not suggestive to BP.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 12)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0006811	ion transport	biological process	TAS	18
GO:0005887	integral component of plasma membrane	cellular component	TAS[7896779]	158
GO:0016020	membrane	cellular component	TAS[7896779]	137
GO:0007586	digestion	biological process	TAS[7896779]	6

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0006810	transport	biological process	TAS[7896779]	47
GO:0055085	transmembrane transport	biological process	TAS	77
GO:0015031	protein transport	biological process	IEA	21
GO:0015992	proton transport	biological process	TAS[7896779]	4
GO:0035672	oligopeptide transmembrane transport	biological process	IEA	1
GO:0005427	proton-dependent oligopeptide secondary active transmembrane transporter activity	molecular function	IEA	1
GO:0015333	peptide:proton symporter activity	molecular function	TAS[7896779]	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
SLC15A1	PDZD3	NO	yeast 2-hybrid	15553237

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
13q21-33	chr13:54700000-109600000	1 (0/0/1)
13q22-32	chr13:72800000-101100000	1 (0/0/1)
13q31-q34	chr13:78500000-114364328	1 (0/0/1)
Chr 13	chr13:0-114364328	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
16380905	This gene is suggestive to SZ/SZA , not suggestive to BP.	Trend

Reference	ID in SZGene	Result Category
16380905	297	Trend

Gene relationship with MDD

View in gBrowse

Region: chr13:98683801..98752654 View in gBrowse