Gene Report

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Basic Info

Approved Symbol	PTPRD
Symbol Alias	PTPD, HPTP
Approved Name	protein tyrosine phosphatase, receptor type, D
Location	9p24.1-p23
Position	chr9:8314246-10612723, -1
External Links	HGNC: 9668 Entrez Gene: 5789 Ensembl: ENSG00000153707 UCSC: uc003zkk.3
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Malhotra, D.,2011		A de novo CNV related with this gene is discovered and validated in our study	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005102	receptor binding	molecular function	ISS	37
GO:0005887	integral component of plasma membrane	cellular component	TAS[7896816]	158
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	molecular function	TAS[7896816]	5

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0030182	neuron differentiation	biological process	ISS	5
GO:0006470	protein dephosphorylation	biological process	TAS[7896816]	10
GO:0005515	protein binding	molecular function	IPI[12570871]	563
GO:0050839	cell adhesion molecule binding	molecular function	ISS	6
GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	biological process	ISS	4
GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway	biological process	TAS[7896816]	3
GO:0035335	peptidyl-tyrosine dephosphorylation	biological process	IEA; TAS[7896816]	9
GO:0006796	phosphate-containing compound metabolic process	biological process	NAS[7896816]	6
GO:0070062	extracellular vesicular exosome	cellular component	IDA[23533145]	176
GO:0097105	presynaptic membrane assembly	biological process	ISS	2
GO:0050775	positive regulation of dendrite morphogenesis	biological process	ISS	2

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 7)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
PTPRD	PPFIA3	NO	in vitro	9624153
PTPRD	PTPRF	NO	in vivo	12376545
PTPRD	PPFIA1	YES	in vitro	8524829
PTPRD	MTSS1	NO	in vitro;yeast 2-hybrid	12570871
PTPRD	PTPRA	NO	in vivo;yeast 2-hybrid	10777529
PTPRD	PTPRS	NO	in vivo	9566880
PTPRD	PPFIA2	NO	in vitro	9624153

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 2)

ID	Location	Size	Band	Type	Inheritance
CNV_Malhotra[2011]_6	chr9:9855970-9927360 (NCBI Build 36 (hg18))	71391	9p23	duplication	De Novo
CNV_Zhang[2009]_190	chr9:9837864-9971069 (Affymetrix SNP 6.0 array reference genome)	133205		Singleton deletions

Gene related other variants (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 9	chr9:0-138394717	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr9:8314246..10612723 View in gBrowse