| Reference |
Tested Markers |
Statistical Values/Author Comments |
Result Category |
Comment on Study |
| Hong, C. J.,2003 |
Other variant: BDNF_Val66Met |
Given the fact that the positive association between BDNF gene Val66Met polymorphism and bipolar disorder has only been demonstrated for a Caucasian population but not for a Japanese analog or our Chinese sample, it appears likely that this association is ethnicity dependent. |
Negative
|
Comment on Study |
| Nakata, K.,2003(a) |
Other variant: BDNF_-1360C>T, BDNF_196G/A |
The results suggest that the BDNF gene is unlikely to confer susceptibility to BPD. |
Positive
|
Comment on Study |
| Sklar, P.,2002 |
Other variant: BDNF_12910C/A, BDNF_-1480C/G, BDNF_3071G/A, BDNF_9202G/A, BDNF_11757C/G, BDNF_14569G/A, BDNF_196G/A, BDNF_-633T/A, BDNF_Val66Met |
This study of 76 candidate genes has identified BDNF as a potential risk allele that will require additional study to confirm. |
Positive
|
Comment on Study |
| Neves-Pereira, M.,2002 |
Haplotype: [BNDF_(GT)n] - (BNDF_val66met)(allele 10-A), [BNDF_(GT)n] - (BNDF_val66met)(allele 1-A), [BNDF_(GT)n] - (BNDF_val66met)(allele 1-G), [BNDF_(GT)n] - (BNDF_val66met)(allele 2-A), [BNDF_(GT)n] - (BNDF_val66met)(allele 2-G), [BNDF_(GT)n] - (BNDF_val66met)(allele 3-A), [BNDF_(GT)n] - (BNDF_val66met)(allele 3-G), [BNDF_(GT)n] - (BNDF_val66met)(allele 4-A), [BNDF_(GT)n] - (BNDF_val66met)(allele 4-G), [BNDF_(GT)n] - (BNDF_val66met)(allele 5-G), [BNDF_(GT)n] - (BNDF_val66met)(allele 7-G)
Other variant: BDNF_(GT)n, BDNF_Val66Met |
Our results suggested that a DNA variant in the vicinity of the BDNF locus confers susceptibility to BP. |
Positive
|
Comment on Study |
| Kunugi, H.,2004 |
Other variant: BDNF_Val66Met |
The Val66Met polymorphism of the BDNF gene is unrelated to the development or clinical features of bipolar disorder, at least in a Japanese population. |
Negative
|
Comment on Study |
| Geller, B.,2004 |
Other variant: BDNF_Val66Met |
This finding in child bipolar disorder is consistent with data for adults with bipolar disorder that show preferential transmission of the Val66 allele. |
Positive
|
Comment on Study |
| Wang, Z.,2012 |
SNP: rs6265 |
Although these results should be interpreted with caution because of the limited sample for Val/Val genotype in BPD-II patients (N = 5), these findings strengthen the hypothesis that BDNF pathway gets involved in the etiology and pharmacology of BPD and suggest the differences between BPD-I and BPD-II. |
Positive
|
Comment on Study |
| Hamshere, M. L.,2012 |
Other variant: BDNF_Val66Met |
The significant interaction effect for the Val/Val genotype of the BDNF Val66Met polymorphism and A1/A2 genotype of DRD2/ANKK1 Taq1A polymorphism was found only in BP-II patients. We provide initial evidence that the BDNF Val66Me and DRD2/ANKK1 Taq1A polymorphisms interact only in BP-II disorder and that BP-I and BP-II are genetically distinct. |
Positive
|
Comment on Study |
| Schumacher, J.,2005 |
SNP: rs6265, rs988748
Haplotype: rs988748 - BDNF_(GT)n - rs6265(C-166bp-G), rs988748 - BDNF_(GT)n - rs6265(C-168bp-G), rs988748 - BDNF_(GT)n - rs6265(C-170bp-G), rs988748 - BDNF_(GT)n - rs6265(C-172bp-G), rs988748 - BDNF_(GT)n - rs6265(C-174bp-G), rs988748 - BDNF_(GT)n - rs6265(G-170bp-A), rs988748 - BDNF_(GT)n - rs6265(G-174bp-A), rs988748 - BDNF_(GT)n - rs6265(G-174bp-G), rs988748 - BDNF_(GT)n - rs6265(G-176bp-A)
Other variant: BDNF_(GT)n |
Our study does not lend much support to a role for BDNF in the etiopathogenesis of BPAD but at the same time cannot unequivocally rule it out. |
Trend
|
Comment on Study |
| Neves-Pereira, M.,2005 |
SNP: rs6265
Haplotype: rs6265 - microsatellite (GT)n(A-(GT1)), rs6265 - microsatellite (GT)n(G-(GT1)) |
Haplotype analysis of val/met SNP and a dinucleotide repeat polymorphism in the putative promoter region revealed highly significant (P<E-08) under-representation of the methionine or met-1 haplotype in the schizophrenic but not the BP population. |
Negative
|
Comment on Study |
| Matsuo, K.,2009 |
Other variant: BDNF_Val66Met |
The findings support an association between the BDNF Val66Met genotype and differential gray matter content in brain structures, and suggest that the variation in this gene may play a more prominent role in brain structure differences in subjects affected with BD. |
Positive
|
Comment on Study |
| Chepenik, L. G.,2009 |
Other variant: BDNF_Val66Met |
In sum, this study of the val66met polymorphism provides preliminary evidence that variation in BNDF has the potential to influence hippocampus structure in BD, and carriers of the met allele may be a subgroup within BD more vulnerable to hippocampus-related deficits. |
Positive
|
Comment on Study |
| Sears, C.,2011 |
SNP: rs10835210, rs11030104, rs11030107, rs11030119, rs12273363, rs1519480, rs6265, rs7103873 |
Our results support the hypothesis that some BDNF gene polymorphisms may be contributing factors in the pathogenesis of BD. |
Positive
|
Comment on Study |
| Neves, F. S.,2011 |
SNP: rs2049045, rs4923463, rs6265, rs7103411 |
No genotypic, allelic or haplotype differences were found between bipolar patients and healthy controls. |
Negative
|
Comment on Study |
| Hosang, G. M.,2010 |
SNP: rs6265 |
The Met containing genotype of BNDF gene was significantly associated with BD. |
Positive
|
Comment on Study |
| Soronen, P.,2011 |
SNP: rs11030102 |
No significant association of this gene was observed in BD. |
Negative
|
Comment on Study |
| Okada, T., 2006 |
Haplotype: BDNF_LCPR - BDNF_Val66Met(A1-Val ), BDNF_LCPR - BDNF_Val66Met(A2-Val ), BDNF_LCPR - BDNF_Val66Met(A3-Val ), BDNF_LCPR - BDNF_Val66Met(A4-Val ), BDNF_LCPR - BDNF_Val66Met(A4-Met ), BDNF_LCPR - BDNF_Val66Met(A5-Val ), BDNF_LCPR - BDNF_Val66Met(A5-Met )
Other variant: BDNF-LCPR |
Our results suggest that the BDNF-LCPR is a functional variation that confers susceptibility to bipolar disorder and affects transcriptional activity of the BDNF gene. |
Positive
|
Comment on Study |
| Skibinska, M., 2004 |
Other variant: BDNF_Val66Met |
No association was found between the studied polymorphism and schizophrenia or bipolar affective disorder either for genotype or allele distribution. |
Negative
|
Comment on Study |
| Huang, C. C.,2012 |
Other variant: BDNF_Val66Met |
BDNF Val/Va: logistic Regression P-value=0.82, OR=1.10, 95% CI=0.47-2.60 in BPI, P-value=0.04, OR=0.40, 95% CI=0.16-0.97 in BPII, BDNF Val/Met: logistic Regression P-value=0.33, OR=1.18, 95% CI=0.54-2.58 in BPI, P-value=0.36, OR=1.39, 95% CI=0.69-2.80 in BPII.
Multiple logistic regression analysis, controlled for age and gender, showed a significant main effect of the Val/Val genotype on the BDNF Val66Met gene in the BP-II group. |
Positive
|
Comment on Study |
| Liu, L., 2008 |
SNP: rs11030104, rs12273363, rs1519480, rs2030324, rs2883187, rs6265, rs7103411, rs7127507, rs7934165, rs988748 |
Evidence of association (p<0.05) was found with several of the SNPs using multiple models of bipolar disorder; one of these SNPs also showed evidence of association (p<0.05) with rapid cycling..
These results provide further evidence that variation in BDNF affects the risk for bipolar disorder. |
Positive
|
Comment on Study |
| Tang, J., 2008 |
Other variant: BDNF_C270T, BDNF_Val66Met |
The study demonstrates that the BDNF C-270T and Val66Met polymorphisms are unlikely to contribute to the genetic predisposition to BPD as a whole. But Val66Met may be associated with susceptibility to the early age of onset subset of the disorder. |
Negative
|
Comment on Study |
| Vincze, I., N., 2008 |
Haplotype: BDNF-LCPR - A-633T - G196A(STG ), BDNF-LCPR - A-633T - G196A(SAG ), BDNF-LCPR - A-633T - G196A(LAA ), BDNF-LCPR - A-633T - G196A(LAG ), BDNF-LCPR - A-633T - G196A(SAA ), BDNF-LCPR - A-633T - G196A(STA ), BDNF-LCPR - A-633T - G196A(LTG )
Other variant: BDNF_196G/A, BDNF_A-633T, BDNF-LCPR |
BDNF G196A (Val66Met) genotypic P-value = 0.0071; Allelic P-value = 0.12.
We replicated the association previously reported between BDNF G196A (Val66Met) polymorphism and BD |
Positive
|
Comment on Study |
| Oswald, P., 2004 |
SNP: rs6265
Haplotype: g.196A_ g.11757G()
Other variant: BDNF_g.11757C>G |
We failed to replicate previous findings implicating BDNF in the aetiology of BPAD |
Negative
|
Comment on Study |
| Chang, Y. H.,2013 |
Other variant: BDNF_Val66Met |
The involvement of the dopaminergic pathway in AD was confirmed, particularly with BP-II rather than BP-I. Because the Val/Val genotype of the BDNF Val66Met polymorphism, rather than the other two polymorphisms, has been associated with anxiety, it seems to affect BP-I comorbid with AD without the involvement of the DRD3 Seg9Gly polymorphism, but may modify the involvement of DRD3 Gly/Gly in BP-II comorbid with AD. |
Positive
|
Comment on Study |
| Lee, S. Y.,2012(a) |
Other variant: BDNF_Val66Met |
We provide initial evidence that the BDNF Val66Met and DRD3 Ser9Gly genotypes interact only in bipolar-II disorder and that bipolar-I and bipolar-II may be genetically distinct. |
Positive
|
Comment on Study |
| Lee, S. Y.,2012(b) |
Other variant: BDNF_Val66Met |
Our findings provide initial evidence that the COMT and BDNF genes interact in bipolar-II without AD. Our findings suggest the involvement of dopaminergic pathway in the pathogenesis of bipolar-II. |
Positive
|
Comment on Study |
| Ivanova, M. A.,2012 |
SNP: rs6265, rs16917237, rs12273363
Haplotype: rs6265 - rs16917237(C-G), rs16917237 - rs12273363(G-T), rs6265 - rs16917237 - rs12273363(C-G-T), rs16917237 - rs12273363(T-T) |
In summary, the current study lends support to the role of BDNF as a predisposing or a modifying factor in the etiology of AD. |
Positive
|
Comment on Study |
| Kanazawa, T., 2007 |
SNP: rs6265 |
The results indicate there is a lack of association between the Val66Met polymorphism of BDNF and either schizophrenia or bipolar disorder. |
Negative
|
Comment on Study |
| Gonzalez-Castro, T. B., 2014 |
SNP: rs6265 |
No significant associations were observed in all models and subgroups. |
Negative
|
Comment on Study |
| Tramontina, J., 2007 |
Other variant: BDNF_Val66Met |
No significant differences were found in the frequency of the BDNF val66met genotype or allele distribution between patients and controls. |
Negative
|
Comment on Study |
| Green, E. K., 2006 |
Other variant: BDNF_Val66Met |
Variation at the Val66Met polymorphism of BDNF does not play a major role in influencing susceptibility to bipolar disorder as a whole, but is associated with susceptibility to the rapid cycling subset of the disorder. |
Positive
|
Comment on Study |
| Kremeyer, B., 2006 |
SNP: rs6265
Haplotype: rs6265 - BDNF_(CA)(Met-221), rs6265 - BDNF_(CA)(Met-223), rs6265 - BDNF_(CA)(Met-225), rs6265 - BDNF_(CA)(Met-227), rs6265 - BDNF_(CA)(Met-229), rs6265 - BDNF_(CA)(Met-231), rs6265 - BDNF_(CA)(Met-233), rs6265 - BDNF_(CA)(Val-219), rs6265 - BDNF_(CA)(Val-221), rs6265 - BDNF_(CA)(Val-223), rs6265 - BDNF_(CA)(Val-225), rs6265 - BDNF_(CA)(Val-227), rs6265 - BDNF_(CA)(Val-229), rs6265 - BDNF_(CA)(Val-231), rs6265 - BDNF_(CA)(Val-233)
Other variant: BDNF_(CA) |
These results are consistent with previous studies pointing to a role for BDNF in susceptibility to mood disorders. |
Positive
|
Comment on Study |
| Muller, D. J., 2006 |
SNP: rs2049045, rs2140887, rs3763965
Haplotype: BDNF_hCV11592756 - BDNF_Val66Met(A-G), BDNF_hCV11592756 - BDNF_Val66Met - BDNF_GT(n)(A-G-3), BDNF_hCV11592756 - BDNF_Val66Met - BDNF_GT(n) - rs2049045(A-G-3-G), BDNF_hCV11592756 - BDNF_Val66Met - rs2049045(A-G-G), BDNF_hCV11592756 - rs2049045(A-G), BDNF_Val66Met - BDNF_GT(n)(G-3)
Other variant: BDNF_(GT)n, BDNF_hCV11592756, BDNF_Val66Met |
Within bipolar disorder, variation in the BDNF gene appears to predict risk for developing rapid cycling according toDSM-IV. Incorporating this clinical sub-phenotyping into other studies of the BDNF gene may help to resolve some of the inconsistencies reported thus far concerning BDNFand bipolar disorder. |
Positive
|
Comment on Study |
| Lohoff, F. W.,2005(c) |
SNP: rs6265 |
Results confirm previous findings and suggest that the Val allele increases risk for BPI in patients of European descent. |
Positive
|
Comment on Study |
| Yosifova, A.,2009 |
SNP: rs2049045, rs4923463, rs6265 |
Significant association of SNP in this gene with BD in our population was observed. |
Positive
|
Comment on Study |
| Mick, E.,2009 |
Other variant: BDNF_Val66Met |
We failed to identify an association with the val66 allele in BDNF with pediatric bipolar disorder.. |
Negative
|
Comment on Study |
| Xu, J., 2010 |
SNP: rs6265 |
We found that the BDNF genotype is associated with BPD in this population. |
Positive
|
Comment on Study |
Gene related studies (count: 37)
Gene related interactors from protein-protein interactions data in HPRD (count: 6)
